Award Data

DESCRIPTION (provided by applicant): A commercially viable recombinant subunit vaccine to prevent West Nile virus infection is the overall objective of this project. West Nile virus was isolated for the first time in North America in 1999. In less than three years, the geographical distribution of the virus expanded dramatically in the United States. A vaccine will be an important complement to ...

Arthropod-borne viruses (arboviruses) present a substantial threat to human and animal health worldwide. They are transmitted by hematophagous arthropods, in which mosquitoes are one of the main transmitters. The mosquito specie, Aedes aegypti, is the primary mosquito vector of several widely spread arboviruses as zika, dengue or West Nile viruses. Mosquitoes transmit these pathogens by inoculatin ...

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DESCRIPTION (provided by applicant): Plasmodium vivax (Pv) is the 2nd most important human malaria parasite, causing gt 80 million cases annually. However, efforts to prevent and control Pv malaria face major challenges of drug resistance and repeated relapses from dormant forms. Moreover, Pv vaccine development has been impeded, because Pv parasites cannot be grown in continuous in vitro culture. ...

DESCRIPTION (provided by applicant): Allergy is a major cause of illness and disability with an estimated 40-50 million people afflicted in the US alone. AIT provides long-term benefits for the patient and its need for optimization creates a compelling business opportunity. There is a very strong rationale to develop GLA for allergy based on its superior drug profile to MPL, a related TLR4 agonist ...

A mobile computing application will be developed for Apple iOS and Google Android based mobile devices. This application will be targeted towards healthcare providers who make routine use of mobile devices in their daily work. The application will be capable of capturing all information required for submission to the Vaccine Adverse Event Reporting System (VAERS) and securely transmitting the info ...

THIS RESEARCH WILL LEAD TO THE DEVELOPMENT OF A VACCINE THAT CAN BE USED TO PROTECT YOUNG CHILDREN AGAINST INFECTIONS CAUSED BY HAEMOPHILUS INFLUENZAE TYPE B (HIB). THE VACCINE WILL BE BASED ON THE PILI THAT FACILITATE THE ORGANISM'S ADHERENCE TO THE NASOPHARYNGEAL EPITHELIUM. ANTIBODIES PRODUCED IN RESPONSE TO THE VACCINE WILL BIND TO HIB PILI, PREVENTING ADHERENCE AND COLONIZATION, AND THEREBY L ...

SIV infection of rhesus macaques serves as a valuable model for HIV infection in humans. Both virusthrough the CD4 T-lymphocyte receptor and are infectious and cytopathic for CD4+ T-lymphocytes and mviruses are genetically closely related: SIV shares approximately 50 percent homology with HIV-1 andhomology with HIV-2. In SIV- infected rhesus macaques, as in HIV-infected humans, a predominantly asi ...

The overall aim of our studies is to derive a potential HCV vaccine, based on the induction of HCV-To do so, we will identify a synthetic formulation composed of at least two A2-restricted CTL epitopconserved regions of the HCV genome. Such formulation will also contain universal T helper epitopesdemonstrated to be efficacious in inducing specific A2-restricted CTL responses in vivo, utilizing Hmi ...

The overall aim of our studies is to derive a potential HCV vaccine, based on the induction of HCV-To do so, we will identify a synthetic formulation composed of at least two A2-restricted CTL epitopconserved regions of the HCV genome. Such formulation will also contain universal T helper epitopesdemonstrated to be efficacious in inducing specific A2-restricted CTL responses in vivo, utilizing Hmi ...