Award Data

Current methods available to measure Blood Alcohol Concentration (BAC) and the biological response of alcohol in individuals are mostly limited to cumbersome breathalyzer or blood tests. The NIAAA seeks a wearable or otherwise discreet device capable of measuring, recording, and storing blood alcohol levels in real time. Alcohol biosensors that are discreet and provide continuous alcohol use monit ...

To-date, the realization of high-performance rocket propulsion systems in small thrust classes (~100lbf) has largely been limited by the inability to create small-scale, regeneratively-cooled, pump-fed engines. Ventions proposes to overcome this limitation by using a novel fabrication technique to realize significant weight and volume savings in a baseline interceptor with high T/W for MDA missio ...

The proposed Phase I work effort will achieve the following objectives: (1) Determine the feasibility of simulating. CASS digital functions in software, (2) Develop a fundamental approach for the creation of an integrated diagnostic tool that allows for digital fault verification in an integrated test software environment. (3) Investigate development of improved digital diagnostic algorithms that ...

The proposed Phase I work effort will achieve the following objectives: (1) Determine the feasibility of simulating. CASS digital functions in software, (2) Develop a fundamental approach for the creation of an integrated diagnostic tool that allows for digital fault verification in an integrated test software environment. (3) Investigate development of improved digital diagnostic algorithms that ...

In this Fast track SBIR grant we aim, by the end of Phase II, to prepare and commercialize a fully humanized rat with Knock-out of many rat drug metabolism related CYP450's (9-in-9-out Rat Drug Metabolism-CYP450 Model) and Knock-in of the human counterpart. IN PHASE I we will develop an Active Genes: Gene Drive (AG:GD) rat - a rat with a properly configured Cas9 to power Active Genetics (AG); AND, ...

In this Fast track SBIR grant we aimby the end of Phase IIto prepare and commercialize a fully humanized rat with Knock out of many rat drug metabolism related CYPsinout Rat Drug Metabolism CYPModeland Knock in of the human counterpartIN PHASE I we will develop an Active GenesGene DriveAG GDrata rat with a properly configured Casto power Active GeneticsAGANDwe will prepare the first CYPKout KinCYP ...

This Small Business Innovation Research (SBIR) Phase I project is the development of a lung tissue model based on a new cell culturing platform utilizing nanoparticle-based reagents and magnetic fields to levitate tissue samples and allow three-dimensional (3D) growth. This method naturally grows tissue at the air-liquid interface and is well suited for co-culturing, which are crucial for an accur ...

DESCRIPTION (provided by applicant): Currently available models for toxicity screening are not always accurate predictors of toxicity in humans. Animal models are commonly used, but they are costly, time-consuming, and ethically challenging, they vary between species, and they do not accurately predict toxicity in humans. In vitro toxicity tests have been explored for years as cheaper alternatives ...

DESCRIPTION (provided by applicant): Several disorders in reproductive medicine are results of changes in smooth muscle contractile activity. Increased myometrial contraction can lead to preterm labor, which affects 12% of the US population. However, the mechanisms involved in the transition from uterine quiescence to contractility at the onset of labor are not well-known. As a result, the managem ...

This Small Business Technology Transfer Research (STTR) Phase I project proposes to develop a design tool for magnetohydrodynamic (MHD) based microfluidic devices. SFC Fluidics' exclusive MHD microfluidic technology has the potential to play an important role in the emerging microfluidic applications market, but this requires the availability of an application development design tool for MHD micr ...