Award Data

In this Small Business Innovation Research effort, Nikira Labs Inc. proposes to develop a sensitive (

Sepsis is the greatest danger after hemorrhage in both civilian and combat-related injuries with mortality rates ranging between 19.5 - 23%. Early intervention with appropriate antibiotics, hemodynamic optimization, and supportive care are particularly vital in preventing trauma related sepsis. Treatments to prevent trauma sepsis may be confounded by the uncontrolled bleeding which often atte ...

Sepsis is the greatest danger after hemorrhage in both civilian and combat-related injuries with mortality rates ranging between 19.5 - 23%. Early intervention with appropriate antibiotics, hemodynamic optimization, and supportive care are particularly vital in preventing trauma related sepsis. Treatments to prevent trauma sepsis may be confounded by the uncontrolled bleeding which often attends s ...

Project Summary/Abstract Quantifying the presence, function, and fate of different immune cells is crucial in immunology and immuno- oncology research, as well as in the diagnosis of hematologic disorders. Flow cytometry is the current method of choice to measure different proteins expressed by single cells at high throughput. However, spectral overlap between fluorophore labels makes flow measure ...

Project Summary High-throughput screens are the workhorse of the early drug discovery process. Millions of biochemical or cell-based assays are conducted to test the activity of small molecules, antibodies and oWher compoXndV Wo idenWif\ ³hiWV´ or drXg candidaWeV for fXrWher study, including pre-clinical and clinical studies. However, the most used technologies for high-throughput screening, suc ...

Abstract Quantifying the presence, function, and fate of different immune cells is crucial in immunology research and development of immunotherapies. Flow cytometry is a single-cell technique that is widely used to measure different protein markers expressed by immune cells at high throughput. However, spectral overlap between fluorophore labels makes measurement of more than 20 markers difficult, ...

Under microscopeit is easy to identify cells of specific morphological phenotypes or interacting with other cell typesBut it is not trivial to pick the very cell out without submicron precision mechanical instrumentmicro pipetting or laser micro dissectionTo facilitate image based single cell isolationwe seek to develop an LCD aided selection under microscopeLASUMtechnology that will allow us to p ...

Abstract Characterizing both functional and genetic heterogeneity among a pool of cells remains a major scientific challenge in immunology, cancer research, neurobiology and developmental biology. Isolating cells with the same phenotype is key to understand such heterogeneity. We would like to develop a non-fluidic, unique technology, LCD aided selection under microscope (LASUM, Fig.1) to address ...

The long term goal of this proposal is to develop a fast, hands-free platform that integrates tissue dissociation, clone characterization and isolation to support the growing field of single celll multiomics. During the phase I of the proposal, enrich will adapt the exiting image based, debris-resistant clone isolation machine by developing essential reagents, protocols and consumables for in-plac ...

PointPro, Inc. offers a computational platform that performs adaptive, closed-loop predictive simulations in order to support the Air Force in its sustainment operations. The future of sustainment is in prescriptive analytics: predicting what will fail, when & how it will fail, and, what can be done about it? Prescriptive analytics demands timely, accurate forecasts of a system’s path to failure ...