Award Data

The goal of this investigation is to develop the invasin gene as a vaccine against M. tuberculosishuman host. Up to the present time, the only known and generally accepted vaccine-BCG-is a living athas shown variable efficacy in the countries where it has been used. Although efforts by other invesof obtaining non-viable vaccine have not proved successful, the concept of a new candidate vaccine cpr ...

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P30, THE MAJOR SURFACE ANTIGEN OF THE TOXOPLASMA GONDII TACHYZOITE STAGE, HAS BEEN ISOLATED FROM THE PARASITE AND SHOWN TO PROTECT MICE FROM A VIRULENT T. GONDII CHALLENGE. THE CDNA ENCODING P30 HAD BEEN CLONED AND EXPRESSED IN E. COLI, PRODUCING RECOMBINANT PROTEIN THAT WAS POORLY RECOGNIZED BY ANTIBODY TO NATIVE PROTEIN. THE SPECIFIC AIM OF THIS PROJECT IS TO DEMONSTRATE THAT RECOMBINANT P30 CAN ...

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DESCRIPTION (provided by applicant): An effective vaccine is the only practical way to halt the AIDS epidemic. The greatest challenge in developing an effective HIV vaccine is antigenic variation. Therefore, the present project aim is to enhance the understanding of antigenic variation by characterizing intra-subtype sequence variation among gpl20 genes from incident (new) infections, and identi ...

DESCRIPTION (provided by applicant): An effective vaccine is the only practical way to halt the AIDS epidemic. The greatest challenge in developing an effective HIV vaccine is antigenic variation. Therefore, the present project aim is to enhance the understanding of antigenic variation by characterizing intra-subtype sequence variation among gpl20 genes from incident (new) infections, and identi ...

DESCRIPTION (provided by applicant): Venezuelan, eastern, and western equine encephalitis viruses (VEEV, EEEV, WEEV respectively) are arthropod-borne alphaviruses that cause periodic epizootics in the Americas. No licensed vaccines exist for these pathogens, and the experimental vaccines used under Investigational New Drug status suffer from high reactogenicity or poor immunogenicity. Vaccines aga ...

DESCRIPTION (provided by applicant): Candida is a fungus that is among the most common causes of infections in hospitalized patients in the United States and worldwide. Candida spp. are one of the most common microbes that infect the blood and urine of hospitalized patients. The cost associated with Candida blood infections alone exceeds at least $1 billion per year in the US. Even with therapy, 4 ...

DESCRIPTION (provided by applicant): Candida is a fungus that is among the most common causes of infections in hospitalized patients in the United States and worldwide. Candida spp. are one of the most common microbes that infect the blood and urine of hospitalized patients. The cost associated with Candida blood infections alone exceeds at least $1 billion per year in the US. Even with therapy, 4 ...

DESCRIPTION (provided by applicant): Candida species are opportunistic fungal pathogens that have become among the most common causes of nosocomial infections in the United States and worldwide. Disseminated infections caused by Candida spp. have increased 15-fold in incidence in the last 15 years, and Candida is now the third most common cause of bloodstream infections. Even with modern antifunga ...