Award Data

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HEPATITIS B VIRUS (HBV) IS A HEPATOTROPIC VIRUS THAT IS A MAJOR PUBLIC HEALTH CONCERN WORLDWIDE. WHILE A RECOMBINANT SURFACE ANTIGEN VACCINE IS AVAILABLE, THERE IS NO EFFECTIVE TREATMENT FOR THE MILLIONS OF INDIVIDUALS WHO ARE CHRONICALLY INFECTED. THE OBJECTIVE IS TO DEVELOP PEPTIDE THERAPEUTICS THAT WILL GENERATE CYTOTOXIC T LYMPHOCYTES (CTL) IN VIVO AND MAY AMELEIORATE CHRONIC HBV INFECTIONS. T ...

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A MODEL WILL BE DEVELOPED TO CREATE EFFECTIVE VACCINE VECTORS THAT WILL ELICIT MUCOSAL (SECRETORY) IMMUNITY. RECOMBINANT VACCINIA VIRUS THAT EXPRESS ONE OR MORE ANTIGENSOF THE PSEUDORABIES VIRUS (PRV) WILL BE USED AS THE PROTOTYPE IN THE DESIGN OF THE FIRST-GENERATION VECTORS. THE LD50 (THE DOSE LETHAL FOR 50 PERCENT OF THE ANIMALS CHALLENGED) OF PRV IN MICE WILL FIRST BE DETERMINED AFTER INTRAPER ...

DESCRIPTION (provided by applicant): The SBIR proposal addresses a critical national need for therapies to treat complications from smallpox vaccination. Vaccination against smallpox is accompanied with numerous adverse reactions, some of which have high fatality rates. Ironically, it was the eradication of smallpox, which the WHO declared complete worldwide in 1979, and the cessation of routine i ...

DESCRIPTION (provided by applicant): The need for nimble technology platforms to counter bioterrorism threats motivates the research proposed here. In this project, reagents with high affinity and specificity for vaccinia virus proteins will be select

"AASC, in collaboration with team member General Dynamics, Space Propulsion Systems, proposes to advance the Vacuum Arc Thruster (VAT) one step closer to flight qualification status. Phase I successfully demonstrated the low system mass and performancecharacteristics necessary to support "precision propulsion" requirements for constellation based, nano satellite missions. Phase II will benchmark t ...

Alameda Applied Sciences Corporation proposes to develop a new type of nano-thruster electric engine for highly parallel, distributed constellations of nano-satellites and other space propulsion applications. A key feature of the proposed Phase-I is theuse of an Inductive Energy Store (IES) driver to power the vacuum arc nano-thruster, which has a mass of 90% PPU efficiency from 1-10 W. The provin ...

Soft lithography is an inexpensive and fast method for applying micropatterned structures to both flat and nonplanar substrates. A vacuum-assisted Micromolding in Capillaries (MIMIC) technique will be developed to print a fine electromagnetic interference (EMI) grid on the inner surface of transparent spinel domes. A photocurable silver filled resin will infiltrate an EMI grid channel patterned ...

Not Available Naval and Marine Corps aircraft systems, subsystems, and components are typically designed to minimize failure due to severe lightning strikes. To minimize the effects of lightning strikes, the aircraft's exterior surface incorporates a copper mesh that is covered with an anti-static paint. This technology suffers from the high cost and difficulty of depainting and repairing damaged ...