Award Data

Project Summary/Abstract The World Health Organization has reported over 216 million confirmed cases of COVID-19 infections and over 4.5 million deaths world-wide as of August 31, 2021. The rapid introduction of this new coronavirus into a previously unexposed (`naive') population has resulted in a pandemic with tragic consequences on a global scale. Although epidemiological data suggests that man ...

Project Summary The global submucosal injection solution market is estimated to be around $3 billion according to the incidence and prevalence rates of medical diagnoses known to be associated with endoscopic mucosal resection/endoscopic submucosal dissection (EMR/ESD), and the market is driven by the need to improve injectability and prolonged submucosal elevation. To date, only three submucosal ...

Antibodies are incredibly powerful tools in basic research and clinical testing because they offer exquisite specificity and affinity in detecting proteins of interest in complex mixtures. They have played a particularly useful role in monitoring post-translational modifications, such as phosphorylated threonine resides, which often regulate a protein's biochemical activity and cellular location. ...

AbstractBladder cancer comprises 7% of new cancer diagnoses in the US. It is the sixth most prevalent malignancy, and has the highest lifetime treatment costs among all cancer types due to the need for lifelong surveillance. Early stage bladder cancer, also known as non-muscle-invasive bladder cancer (NMIBC), represents 75% of new bladder cancer cases. The standard treatment is transurethral resec ...

Project SummaryThe mucus layer is the first line of defense against infiltration of microorganisms, digestive enzymes and acids, digested food particles, microbial by-products, and food-associated toxins. This layer coats the interior surface of the GI tract, lubricates luminal contents and acts as a physical barrier to bacteria and other antigenic substances present in the lumen. The moist, nutri ...

PROJECT SUMMARY There is a clear unmet need for new differentiated anti-hypertensive therapies, as high blood pressure and its pathological sequelae remain significant burdens to human health despite several classes of approved drugs. The vascular endothelium is a dynamic interface that regulates vasotone, inflammation, hemostasis and vascular remodeling. Dysfunction of the vascular endothelium, i ...

Project Abstract Several currently administered antibiotics raise two main concerns: resistance and non-selectivity. The rapid rate of emerging multi-drug resistance poses a global health threat and dramatically increases economic burden. With traditional antibiotics being largely non-selective, there are serious side effects due to the natural host microbiome being modified, and thus a loss in ho ...

Culture and amplification-free bacterial sepsis diagnosis Summary Sepsis is a life-threatening complication of an infection that requires immediate treatment. The identification of the causative microorganism utilizing processes based on blood culture is a keystone of sepsis diagnosis. However, blood culture takes one to five days to provide results. Here, we propose the development of a culture a ...

Project Summary Ambient air pollution is a leading contributor to global disease burden that increases morbidity and mortality, and it accounted for 4.2 million deaths in 2015. Mineral dusts are a constituent of total atmospheric particulate matter that affect global biogeochemical cycles, pollute water bodies and air masses, and impact global climate. Dust presents physical (i.e., reduced visibil ...

The objective of this proposal is to develop a novel device to provide leg heat therapy (HT) for patients with symptomatic peripheral arterial disease (PAD). The current non-interventional standard of care for PAD is a 12 week program of supervised exercise therapy (SET). For patients this is often very painful as they are exercised to the point of claudication and many elderly patients find it di ...