Award Data

The availability of liquid biopsies such as sampling of blood to measure key disease biomarkers could aid in the detection of blood circulating tumor DNA ctDNA known to confer resistance to cancer therapy For example the T M mutation in the epidermal growth factor EGFR accounts for of acquired resistance to FDA approved EGFR targeted therapies Detection of this mutation is important ...

Multidrug resistant organisms MDROs are responsible for over million hospitalization cases and deaths annually in the U S The lack of effective antibiotic therapies against resistant pathogens leads to increased mortality increased hospital length of stay and excessive direct healthcare costs as high as $ billion yr Monitoring the MDROs in the gastrointestinal tract is therefore c ...

Fungal endophthalmitis is an infection inside the eye after corneal transplant surgery caused by contamination of the transplanted tissueAccording to the Eye Bank of Americathe incidence of postsurgery endophthalmitis more than doubled fromtoand thatof the culture positive cases were due to Candida yeastEnvironmental contamination as well as current corneal preservation conditions contribute to th ...

The wide availability of rapidfield portablelow costand sensitive molecular diagnostic for point of care detection of malaria parasites would have a significant benefit for intervention programs aimed at eliminating malaria in affected populationsMalaria remains one of the most serious infectious diseases in low income countriesthreatening nearly half of the world s population and causing an estim ...

This Phase II SBIR project builds upon previous research to develop an increased life cycle, high-energy, lightweight, cost-efficient 1 Ah prototype battery designed specifically to support the next generation of powered prosthetic devices. Currently, prosthetic power supplies are not specifically designed for these applications and present a major hurdle for prosthetic design engineers. The Giner ...

Legionnaires’ disease is a lung infection caused by Legionella bacteria which typically leads to severe pneumonia or a mild flu-like illness known. Legionella bacterial infections are estimated to cause 8,000 to 18,000 hospitalizations annually and account for 2% to 9% of all reported pneumonia illnesses. Legionella is transmitted to people through inhalation of Legionella-containing water dropl ...

Alcohol use disorder (AUD) has devastating effects on human health, there is a need for new tools to better understand, diagnose, and treat AUD. Improved technology that enables to accurately measure alcohol levels in real-time would be transformative in understanding binge behavior of those who suffer from AUD and would lead to better treatment strategies. The overall goal of this program is to d ...

The public health impact of endemic fungal diseases is increasingly becoming more widespread as they have high morbidity and mortality especially in immune-compromised patients. There is an urgent need for early and accurate diagnosis of these diseases. However, current medical diagnostics are insufficient to meet adequate clinical requirements. The overall goal of this project is to develop a low ...

To develop rapid, point of care diagnostics for hepatitis C virus.

Current methods available to measure Blood Alcohol Concentration (BAC) and the biological response of alcohol in individuals are mostly limited to cumbersome breathalyzer or blood tests. The NIAAA seeks a wearable or otherwise discreet device capable of measuring, recording, and storing blood alcohol levels in real time. Alcohol biosensors that are discreet and provide continuous alcohol use monit ...