Award Data

This SBIR project aims to implement a federated data platform focused on a data system to enable mammography data to be published into a federated catalog from which collaborators can execute federated analyses. It will enable hospitals and other clinical entities to make their data available for training and validation of artificial intelligence applications. The data federation will include a ra ...

Surgical resection is required in approximately 80% of cancers presenting solid tumors. Despite advancing technologies, countries categorized as LMICs show an increase in incidences of various cancers. The lack of preventative screenings, and the associated infrastructure, make both identification and screening of cancers difficult. The long-term objective of this work is to build a benchtop CO2 l ...

Cervical cancer is a major disease globally and 85% of the cancer burden occurs in low- and middle-income countries (LMICs). Standard of care is external-beam radiotherapy with high dose-rate brachytherapy (HDRBT). Adding brachytherapy to the treatment course improves overall survival by 12% and reduces local recurrence. HDRBT treatment planning is a complex process. Brachytherapy in low-resource ...

MRIMath technology uses Artificial Intelligence (AI) to deliver pixel-level contouring of brain tumors from surrounding healthy tissue to shorten the time it takes to plan radiation treatment, reduce variability among oncologists, and boost patient outcomes. Tumor delineation and quantification remains the weakest link in the search for accuracy in radiotherapy. Inaccuracy and variation in definin ...

The tumor microenvironment (TME) comprises a mixture of cell types, including tumor cells, cancer sub-clones, metaplasia, dysplasia, desmoplasia, reactive fibroblasts, and a complex immune response. Measuring the molecular status of each cellular component within the TME is important to understanding tumor initiation and progression as well as in determining the interplay between cancer and normal ...

One of the major factors limiting pre-clinical and clinical use of FLASH RT is the difficulty in measuring the FLASH irradiation parameters such as dose, dose per pulse, pulse repetition frequencies, and time structure with the available conventional radiation detectors, electrometers, and dosimetry protocols. The goal of this project is to design and construct a novel NIST-traceable ionization ch ...

The objective of this project is to produce software that can de-identify and anonymize WSI and CT data in a reliable, efficient manner. The end result will be a software product that can be used by the pathology and medical research community to share data while minimizing the risk of exposing PHI/PII.

Locus Health, in this Phase II effort, will further develop and demonstrate the utility and commercial viability of its scalable, HIPAA-compliant Cancer Navigation Platform. The long-term goals of this Platform are to improve cancer patient outcomes and the efficiency and quality of patient navigation. Building on Phase I results, the project team will further develop the Platform’s patient enga ...

Cervical cancer (CC) has a high prevalence in low- and middle-income countries (LMICs) and remains the leading cause of cancer deaths among women, despite the remarkable improvements in prevention seen in wealthier countries. Privo Technologies intends to bridge this healthcare gap with PRV311, a nanoengineered standalone and cost-effective treatment for localized delivery of chemo-loaded nanopart ...

Cancer is the second leading cause of death in the United States and esophageal cancer has the 6th lowest survival rate for all cancers. Systemic drug therapy is first-line therapy for widely metastatic esophageal cancer, but is limited by systemic toxicity, patient eligibility, or cost. The proprietary Isola system consists of a drug delivery catheter, tubing, heating element, and a drug lavage s ...