Award Data

Project Summary/Abstract: The overall objective of this study is to develop a novel, predictive in vitro platform for studying physiological responses of the cellular layers of the anterior eye for therapeutics. Current in vitro models mostly rely on a single cellular architecture of the corneal epithelium and do not mimic the in vivo physiological relevance of cell-cell and cell-ECM interactions. ...

The run time of the Aerodynamic and Propulsion Test Unit (APTU) facility operated by the Air Force Test Center (AFTC) requires extension to approximately 1000 seconds in order to support hypersonic system ground test and evaluation over an entire mission profile in a similar fashion has the Space and Missile Defense Command (SMDC) Hot Air Tunnel (HAT) effort.   CFD Research is leveraging prior i ...

The AeroDefense drone and pilot (controller) detection, location and alert system operates on a physical signal level. The system scans 400/900 MHz and 2.4/5.8 GHz for Radio Frequency (RF) signals with similar power, frequency-hop and other physical characteristics to those used by drones and their ground station controllers. If the drone signature is in the AeroDefense system database, manufactur ...

The Air Force (AF) has yet to leverage broad and operator-based machine learning (ML) into their maintenance, mission, or operational environments. Falkonry’s commercially demonstrated “Data Scientist in a Box,� is a pre-packaged operational ML solution that empowers teams with pattern discovery, predictive analytics, and explanation to improve uptime, performance, quality and ...

Falkonry LRS is your “Data Scientist in a Box,â€ï¿½ pre-packaged operational machine learning (ML) empowers your teams with pattern discovery, predictive analytics and explanation to improve uptime, performance, quality and safety. Falkonry believes its AI-enabled LRS could add significant value to the processing of electronic intelligence (ELINT) data, at scale and for significantly l ...

DESCRIPTION (provided by applicant): Identifying the regulatory regions of the genome is critical for understanding the regulatory networks underlying human development and disease. Chromatin immunoprecipitation (ChIP) coupled with microarray (ChIP-chip) or sequencing (ChIP- seq) is a widely used technique for understanding the genome-wide binding pattern of regulatory proteins. A key bottleneck ...

Many of the antibodies produced for cancer research are poorly characterized, exhibit suboptimal affinity or selectivity, and are time-consuming and expensive to produce. Alternative affinity capture reagents are therefore needed as reproducible, highly characterized, rapid, and cost-effective substitutes for monoclonal antibodies. As a platform for creating affinity capture reagents, Aptakon has ...

The function of many cancer related proteins is modulated by modifications such as phosphorylation and glycosylation. The development of antibodies that recognize site-specific phosphorylation has vastly improved our understanding of signal transductionand cancer cell physiology and regulation. However, almost no available antibodies recognize site specific glycosylation, and in particular, N-a ...

The goal of this Phase I SBIR project is to develop a set of high resolution antibody mimeticsnanoCLAMPsoptimized for super resolution imaging of a broad range of subcellular structuresAdvances in super resolution microscopy have enabled the achievement of resolutions well below the diffraction limit with current techniques now approachingnmFor immunostainingthenm size of antibody complexes now li ...

The goal of this Phase I SBIR project is to develop affinity reagents useful for the sub fractionation of specific exosomal populationsBecause exosomal makeup and cargo reflect the typedevelopmental stageand the disease state of the cells they are shed fromthey are attractive targets for non invasive diagnosticsExosomes are also being investigated for therapeutic applications such as vaccines and ...