Award Data

Prostate cancer is the most common diagnosed cancer developing in men, developing in around 160,000 men in the United States. While many men are successfully treated of the disease, nearly 30,000 continue to die each year to do an advanced cancer which continues to grow despite castration levels of androgen present. A new generation of androgen receptor signal inhibitors has come to the market and ...

Multidrug resistance tuberculosis (MDR-TB) is a global healthcare concern compounded by poor compliance associated with lengthy drug susceptible TB (DS-TB) treatment regimens. Clofazimine (CFZ) is highly active against MDR-TB, but oral use is limited by systemic toxicity (hyperpigmentation, GI effects, and QT prolongation). Inhalation of CFZ will overcome these limitations by achieving high local ...

PROJECT SUMMARY Mycobacterium abscessus (Mab) lung infections are extremely resistant to drug therapy and are growing in prevalence, particularly in the cystic fibrosis community where they are associated with decreased lung function and a high mortality rate. Current treatment guidelines recommend a two-year regimen of a combination of four antibiotics that are associated with numerous systemic t ...

The incidence and mortality rates of cutaneous squamous cell carcinoma (cSCC) and skin cancer continues to increase. It is expected that 1 in 5 Americans will develop skin cancer in their lifetime. Although surgical excision is typically indicated and effective, surgery is not always appropriate or possible. Efforts to treat and/or prevent using pharmacological agents are limited by poor delivery ...

TO DEVELOP LOW-COST, SHELF-STABLE, PATIENT- ADAPTABLE MINI-TABLETS FOR TREATMENT OF TUBERCULOSIS IN PEDIATRICS

The proposed innovation is a methodology for advanced process control and deposition analysis built around using signals generated by beam-component interactions in the Electron Beam Free Form Fabrication (EBF3) system. These signals have the potential to be used for many forms of both metrology and process control. While many material properties might be studied by using this interaction, our ini ...

The proposed innovation is a methodology for advanced process control and deposition analysis built around using signals generated by beam-component interactions in the Electron Beam Free Form Fabrication (EBF3) system. Based upon our successful Phase I results, hese signals have the potential to be used for many forms of both metrology and process control. While many material properties might be ...

A methodology based on dynamic electron beam imaging of beam-component interactions for in-situ metrology and closed loop real time process control of electron beam wire printing and welding applications in space has been demonstrated at the proof of concept level with hardware, controls and software developed by COSM in Phase I and II programs.A new Electron Beam Delivery Unit (EDU) that has both ...

Room temperature nanoscale energy harvester has been tested for over two years and a micro version has again proven that energy can be continuously harvested at room temperature. Our energy harvester has an energy density of 1550W/L and more than 40 percent greater than any lithium-ion battery. Continuous power, higher energy output, scalable, long lasting (more than one year) and without the asso ...

ABSTRACT: Hole preparation for aircraft manufacturing is the one of the highest manufacturing costs at approximately 30 percent. The current manual method for hole preparation is to drill a pilot hole (typically 0.128-inch diameter) then perform multiple reaming steps to achieve final diameter. Military aircraft and certain areas of commercial aircraft utilize thick, exotic materials to achieve s ...