Award Data

PROJECT SUMMARY The world is immersed in a health crisis rivaled only by the Spanish flu pandemic of 1918-1919. The difference between the crisis of today and the crisis a century ago is that we have advanced communication technology greatly so that huge populations of people around the globe are aware of risks and can take appropriate precautions, such as the employment of quarantining, isolation ...

ABSTRACT Congestive heart failure (CHF) is a chronic and progressive condition that currently affects over 6 million patients in the US. It accounts for over $35B in annual healthcare expenditure and is responsible for over one million hospitalizations each year. CHF is a chronic and progressive condition in which the heart is unable to pump enough blood to maintain adequate circulation - the hear ...

ABSTRACT: Without a pandemic such as COVID-19, the prevalence of Acute Respiratory Syndrome (ARDS) associated with Acute Lung Injury (ALI) is estimated to be ~200-240K patients/year in the US, accounting for 3.6-million hospital days per year and with 30-40% mortality. Considering that US represent only 4.23 % of world population, the likely incidence of ARDS and commercially addressable needs wil ...

AbstractThe growing use of e-cigarettes and vaping devices in recent years is a concern for the health community. While the safety has not yet been fully characterized, these devices are linked to smoking cessation efforts, targeted marketing campaigns towards adolescents, and additives, such as fruit flavors, that promote use. Experimental data has been collected to investigate toxicity, lethalit ...

PROJECT SUMMARY The Nautilus pump is a centrifugal, totally implantable, compact, long-lasting partial circulatory assist device implanted via a minimally invasive pacemaker pocket approach to support LV function for late-stage heart failure intervention. The Nautilus pump will be connected to the systemic circulation by attachment of the pump’s inflow port to a cannula placed into the subclavia ...

Project Summary IDOC Software proposes the development of Artificial Intelligence (AI) algorithms, together with user-friendly software, for facilitating the efficient production of Systematic Reviews (SRs) in the field of Environmental Health (EH). SR is the “Gold Standard” for assessing evidence to be used for decision making in a variety of health contexts, including health care, public hea ...

ABSTRACT This study aims to further develop and test our voice-activated technology to deliver components of cognitive behavioral therapy for insomnia (CBT-I) to breast cancer survivors (BCS). CBT-I is a structured, systematic program which delivers better and safer outcomes than prescription sleep medications. Non-pharmacologic approaches target physiologic, cognitive, behavioral, environmental, ...

Therapeutic monoclonal antibodies bind to specific regions of proteins called epitopes, which elicit cellular responses that treat or cure disease. Discovering therapeutic antibodies traditionally requires laborious and expensive screening experiments, so computational approaches that select which antibodies bind an epitope best and have the most desirable pharmaceutical properties are in high dem ...

Summary Claremont BioSolutions, LLC (CBIO) The ability to sequence and map long stretches of DNA and RNA using third generation sequencing technologies is set to transform the field of genomics and allow researchers and clinicians unparalleled insight into the complexities of our genome and diseases. However, the move to these platforms presents new hurdles in long DNA and RNA sample preparation. ...

PROJECT SUMMARY Collaborative Drug Discovery, Inc. (CDD) proposes to develop a novel intelligent data browser that will enable medicinal chemists developing new drug compounds to more efficiently browse and organize experimental data in an intuitive way. The proposed browser will essentially “hyperlink” chemical space and allow chemists to navigate easily among compounds in a chemical lead ser ...