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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 196141 - 196150 of 204654 results
  1. Nanomaterial Radioisotope Detectors for Intracellular Measurements

    SBC: SCINTILLATION NANOTECHNOLOGIES INC            Topic: 400

    The capability to analyze cellular uptake of physiological and pharmacological compounds with increasing sensitivity and temporal resolution plays a critical role in understanding the underlying molecular pathways involved in human diseases and disorders. Among the most challenging analytes are those present at very low concentrations with high temporal variability, and small molecules lacking moi ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Discovery of Novel Anti-inflammatory, Non-immunosuppressive Molecules forMitigation of Cytokine Storm in COVID-19 Patients

    SBC: OROX BIOSCIENCES INC            Topic: NHLBI

    Project Summary/Abstract The World Health Organization has reported over 216 million confirmed cases of COVID-19 infections and over 4.5 million deaths world-wide as of August 31, 2021. The rapid introduction of this new coronavirus into a previously unexposed (`naive') population has resulted in a pandemic with tragic consequences on a global scale. Although epidemiological data suggests that man ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  3. Multifunctional injectable agent for endoscopic mucosal resection

    SBC: ALEO BME INC            Topic: 300

    Project Summary The global submucosal injection solution market is estimated to be around $3 billion according to the incidence and prevalence rates of medical diagnoses known to be associated with endoscopic mucosal resection/endoscopic submucosal dissection (EMR/ESD), and the market is driven by the need to improve injectability and prolonged submucosal elevation. To date, only three submucosal ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. Wastewater data integration and modelling to accurately predict community and organizational outbreaks due to viral pathogens

    SBC: SUPERIOR STATISTICAL RESEARCH LLC            Topic: NIAID

    Project Summary. The COVID-19 pandemic has magnified the need for enhanced ability to accurately anticipate future outbreaks due to novel and endemic viral pathogens. Without systematic surveillance, the ability to head off outbreaks before they occur is challenging: the data from positive human test results is often too late to prevent a major outbreak from occurring, despite substantial lockdown ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Building a pipeline to generate affinity reagents to phosphothreonine epitopes

    SBC: Tango Biosciences Inc.            Topic: 300

    Antibodies are incredibly powerful tools in basic research and clinical testing because they offer exquisite specificity and affinity in detecting proteins of interest in complex mixtures. They have played a particularly useful role in monitoring post-translational modifications, such as phosphorylated threonine resides, which often regulate a protein's biochemical activity and cellular location. ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Technology-based training to improve learning-to-drive outcomes for autistic persons

    SBC: Minnesota HealthSolutions Corporation            Topic: NICHD

    Project Summary/Abstract The goal of the proposed project is to make the widespread use of an autistic driver training program feasible. Specifically, we plan in phase I to develop an innovative learn-as-you-go training module and in phase II to rewrite the app for a variety of devices and operating systems. The program teaches visual search skills to autistic individuals who are learning to drive ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Community-based Brain Health Program to Address Dementia Risk (C-BBHP)

    SBC: POSIT SCIENCE CORP            Topic: NIA

    PROJECT SUMMARY The goal of the current Phase I proposal is to further develop (to pivotal trial readiness) and evaluate a community-based Brain Health Program to address dementia risk (C-BBHP) that includes multiple intervention modalities affecting diet, exercise and cognitive health designed to extend older adults’ functional independence and improve cognitive performance. This intervention m ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a salt-based nanomedicine for non-muscle invasive bladder cancer

    SBC: ATHNA BIOTECH INC            Topic: 102

    AbstractBladder cancer comprises 7% of new cancer diagnoses in the US. It is the sixth most prevalent malignancy, and has the highest lifetime treatment costs among all cancer types due to the need for lifelong surveillance. Early stage bladder cancer, also known as non-muscle-invasive bladder cancer (NMIBC), represents 75% of new bladder cancer cases. The standard treatment is transurethral resec ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. A Mucus-producing Intestinal Epithelium Model for In Vitro Drug Absorption Testing

    SBC: Altis Biosystems, Inc.            Topic: 300

    Project SummaryThe mucus layer is the first line of defense against infiltration of microorganisms, digestive enzymes and acids, digested food particles, microbial by-products, and food-associated toxins. This layer coats the interior surface of the GI tract, lubricates luminal contents and acts as a physical barrier to bacteria and other antigenic substances present in the lumen. The moist, nutri ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Pharmacological induction of KLF2 and reversal of endothelial dysfunction for the treatment of hypertension

    SBC: RIPARIAN PHARMACEUTICALS INC            Topic: NHLBI

    PROJECT SUMMARY There is a clear unmet need for new differentiated anti-hypertensive therapies, as high blood pressure and its pathological sequelae remain significant burdens to human health despite several classes of approved drugs. The vascular endothelium is a dynamic interface that regulates vasotone, inflammation, hemostasis and vascular remodeling. Dysfunction of the vascular endothelium, i ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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