Award Data

DESCRIPTION (provided by applicant): Rabies is a major global health issue that kills approximately 40,000 to 70,000 people per year and over 10 million people who receive post-exposure prophylaxis (PEP) after exposure to potentially infected animals. Cost and compliance issues have greatly hampered the effectiveness of current vaccines. To confound this issue, current vaccines are not effective ...

DESCRIPTION (provided by applicant): Current human rabies virus (RV) vaccines are effective if administered in an appropriate and timely manner and therefore, RV infection is a vaccine-preventable disease. However, immunization protocols are complex, requiring multiple doses over a period of weeks and in some cases months. High costs and the lack of compliance associated with current vaccines, and ...

DESCRIPTION (provided by applicant): According to the NIAID fact sheet on Botulism, the extreme toxicity of botulinum neurotoxins (BoNT) and the ease of production, transport, and delivery make this an agent of extreme bioterrorism concern. Nonetheless, although there are major vaccine development initiatives ongoing, there currently is no approved Botulinum toxin vaccine available. Advances i ...

DESCRIPTION (provided by applicant): Although a rapid and accurate diagnosis is crucial to the management of patients suspected of bacterial infection, the currently available radiopharmaceuticals are not capable of distinguishing between sterile inflammation and bacterial infections. Our goal is to develop an infection-specific PET/SPECT radiopharmaceutical for eventual use in clinical practice. ...

DESCRIPTION: Tracing neuronal connections with lipophilic carbocyanine dyes has revolutionized neuroanatomical tract tracing and is an essential feature to understand development of brain connections in both control and mutant mice in particular since multiple colors of dyes can be used. More recently, lipophilic dyes have also gained ground in labeling blood vessels by directly staining the endo ...

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There is an urgent need for more effective drug delivery agents for treatment of brain tumors, which are among the most aggressive and intractable cancers. SapC-DOPS, a nanovesicle composed of saposin C (SapC) coupled to dioleoylphosphatidylserine (DOPS), has proven tumor targeting properties, which include crossing the blood-brain tumor barrier and binding the lipid tumor marker, extracellular ph ...

Securboration is pleased to propose an innovative approach to linking Effect Based Operation (EBO) Center Of Gravity analysis with simulation tools to determine the most effective Course Of Action (COA) to achieve the desired effects, entitled EBO-Scenario-Generation. EBO- Scenario-Generation concept is based on five years of research in to automated Scenario Generation capabilities. The ability ...

Securboration Inc. is pleased to propose an innovative approach to the automated creation of complete scenarios, or Scenario Generation (SGen), for mission planning simulation. This approach is a continuation of our Phase I effort, which successfullyvalidated our approach to scenario generation, and refined how scenario generation technology can be directly applied to problems facing the Effects ...

Securboration Inc., teaming with Dr. Eugene Santos of the University of Connecticut, is pleased to propose our innovative approach for visualizing and assessing uncertainty entitled, Uncertainty Prediction System (UPSYS). During the phase one effort weplan to demonstrate how the innovative UPSYS technology can be applied to supports visualization and assessment of event uncertainty within the con ...