Award Data

Pelvic organ prolapse POP is a highly prevalent condition affecting over of women in the US during their lifetimes Urinary incontinence UI affects an estimated of women Both POP and UI are more common in women than in men and their prevalence is increased with age Some loss of utero vaginal support occurs in most adult women however the true etiology of prolapse and differences se ...

Pelvic organ prolapse POP is a highly prevalent condition affecting over of women in the US during their lifetimes Urinary incontinence UI affects an estimated of women Both POP and UI are more common in women than in men and their prevalence is increased with age Some loss of utero vaginal support occurs in most adult women however the true etiology of prolapse and differences se ...

DESCRIPTION (provided by applicant): Chronic pain can result from various disease conditions and about 45% of the U. S. population seeks medical help for treatment of pain. Neuropathic pain is a type of chronic pain which is very difficult to treat, and most patients do not get adequate relief. A promising therapeutic drug target for the treatment of inflammation and pain is the cannabinoid CB2 re ...

Not Available Physical Optics Corporation (POC) proposes to design and develop a new single curvature collimating display screen (CDS) for out-the-window simulator applications. This proposed screen is based on a unique combination of two technologies: a holographic light shaping diffuser (LDStm) with predetermined diffusion properties, integratd with a microlens array. This proposed screen will ...

Project Summary The Specific Aim of this proposal is to test the feasibility of using vagus nerve stimulation VNS for treating asthma related airway constriction that is refractory to current treatments There are approximately million people with asthma in the US About percent of these asthma sufferers experience early and late phase severe asthmatic bronchoconstriction that is refract ...

PROJECT SUMMARY Soluble pre-amyloid oligomers (PAO) are the most potent mediators of cytotoxicity, despite common focus on autophagy as a means to clear larger misfolded protein aggregates. Specifically, PAO, rather than aggresomes, are most correlated with desmin-related cardiomyopathy (DRC) caused by an Arg120Gly missense mutation of αB-Crystallin (CryABR120G). In addition to causing DRC, emerg ...

DESCRIPTION (provided by applicant): Monoclonal antibodies exhibit high specificity for target molecules and for that reason have been successfully utilized as therapeutic and diagnostic agents. The sequence of amino acids comprising the primary structureof an antibody is largely responsible for its binding preference and efficacy. Therefore, antibody sequencing is a central requirement for the de ...

DESCRIPTION provided by applicant Antibodies are ideal drug candidates due to high specificity for target molecules Monoclonal antibodies represent one of the fastest growing segments of the drug market however recent attention has focused on polyclonal antibodies and monoclonal mixtures to reduce the opportunity for a disease to become drug resistant Polyclonal antibodies sampled from dise ...

A procedure and supporting computer code for the prediction of noise that radiates from small, vertical lift UAV aircraft is proposed. The resulting building block procedure is theoretically based but is verified experimentally at several output stages. Noise source models for rotors, lift-fans, engines etc. are developed and validated through specially designed experiments and stored in a compo ...

Navy aircraft employ components that are contoured for aerodynamic performance and made of composite sandwich structures for high strength-to-weight ratio. Many of these components presently use honeycomb cores surrounded by thin high strength face sheets. While honeycomb is used extensively, it can be difficult to form to contoured shapes, must be spliced to reinforce high stress locations, provi ...