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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 196151 - 196160 of 204843 results
  1. Exploiting porcine cytomegalovirus stealth mechanisms

    SBC: Xenocept, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Pig-to-human xenotransplantation may alleviate the critical shortage of organs available for transplantation. However, hyperacute rejection (HAR), acute vascular rejection (AVR), and cell-mediated rejection pose significant immunological hurdles to making xenotransplantation a clinical reality. Now that pigs lacking a functional alpha-1,3-galactosyltransferase ...

    STTR Phase I 2005 Department of Health and Human ServicesNational Institutes of Health
  2. HUMAN KERATINOCYTE STRESS GENE ASSAY

    SBC: Xenometrix, Inc.            Topic: N/A

    N/A

    SBIR Phase I 1996 Department of Health and Human Services
  3. PILOCARPINE PRODRUGS WITH IMPROVED BIOAVAILABILITY

    SBC: Xenon Vision            Topic: N/A

    INTRAOCULAR PRESSURE (IOP) IS NOT ADEQUATELY CONTROLLED BY SINGLE DRUG THERAPY IN MORE THAN 50 PERCENT OF GLAUCOMA PATIENTS. THE DEVELOPMENT OF ADDITIONAL DRUGS TO TREAT GLAUCOMA EITHER ALONE OR IN COMBINATION WITH ADRENERGIC BETA-ANTAGONISTS IS THEREFORE APPROPRIATE. THIS PROJECT SEEKS TO DEVELOP PRODRUGS OF PILOCARPINE. THESE PRODRUGS ARE EXPECTED TO REDUCE THE ELEVATED IOP THAT IS ASSOCIATED WI ...

    SBIR Phase I 1990 Department of Health and Human Services
  4. NOVEL CAI DERIVATIVES FOR TOPICAL APPLICATION

    SBC: Xenon Vision            Topic: N/A

    IN MORE THAN 50% OF GLAUCOMA PATIENTS INTRAOCULAR PRESSURE (IOP) IS NOT ADEQUATELY CONTROLLED BY SINGLE DRUG THERAPY. OPTIC NERVE DAMAGE ASSOCIATED WITH ELEVATED IOP IS THE LEADING CAUSE OF IRREVERSIBLE BLINDNESS IN THE WESTERN WORLD. THE DEVELOPMENT OF ADDITIONAL DRUGS TO TREAT GLAUCOMA EITHER ALONE OR IN COMBINATION WITH CURRENTLY AVAILABLE MEDICATIONS SUCH AS THE ADRENERGIC A-ANTAGONISTS THEREF ...

    SBIR Phase I 1991 Department of Health and Human Services
  5. NEW METHOD FOR TRANSCYTOSIS PATHWAY AND LIGAND DISCOVERY

    SBC: XENOPORT, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Current methods for oral delivery of macromolecular and other drugs poorly absorbed by the intestine do not provide adequate oral bio-availability. Thus, new intestinal pathways to transport larger quantities of compound must be identified. Unfortunately, current methods of pathway identification are inadequate. XenoPort w ...

    SBIR Phase I 2002 Department of Health and Human ServicesNational Institutes of Health
  6. New Method of Transcytosis Pathway and Ligand Discovery

    SBC: XENOPORT, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): XenoPort will use NIH funding to develop a novel phage display method for identifying useful transcytotic pathways for oral administration of therapeutic drugs, and for identification of therapeutic molecules. Current methods for oral delivery of macromolecular and other drugs poorly absorbed by the intestine do not provide adequate oral bio-availability. Thus, ...

    SBIR Phase II 2003 Department of Health and Human ServicesNational Institutes of Health
  7. Enzyme induction in freshly isolated human hepatocytes

    SBC: XENOTECH, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): This is Phase I of an SBIR grant application. The overall goal of this project is to enable the pharmaceutical industry to conduct high-throughput screening (HTS) studies with Fa2N-4 cells, a new cell line created by immortalizing human hepatocytes with SV-40 virus, in order to identify those drug candidates that will likely cause clinically significant drug-dr ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  8. Photonic Technology for RF, Microwave and mmW Antennas

    SBC: XENOTRAN CORPORATION            Topic: N/A

    Xenotran Corporation proposes to develop a new optical true-time-delay antenna steering system suitable for Navy radar and communications systems. The system will be based on the optical commutator, a device that employs fiber optic delay lines which provide exact timing to steer antenna arrays. The end result will be an inexpensive low end commercial market product. Xenotran ...

    SBIR Phase I 1997 Department of DefenseNavy
  9. Demonstration of Optical Control of Steerable Array Antennas

    SBC: XENOTRAN CORPORATION            Topic: N/A

    Xenotran corporation proposes to develop a new antenna system employing an optical true-time-delay steering technique that will be suitable for Army radar. The antenna system will be based on the optical commutator, a device that is capable of switching fiber optic delay lines in an ordered sequence, to provide exact timing necessary to steer antenna arrays in two dimensions. The phase shifters ...

    SBIR Phase I 1997 Department of DefenseArmy
  10. Demonstration of Optical Controls of Steerable Array Antennas

    SBC: XENOTRAN CORPORATION            Topic: N/A

    Xenotran corporation proposes to develop a new antenna system employing an optical true-time-delay steering technique that will be suitable for Army radar. The antenna system will be based on the optical commutator, a device that is capable of switching fiber optic delay lines in an ordered sequence, to provide exact timing necessary to steer antenna arrays in two dimensions. The phase shifters ...

    SBIR Phase II 1998 Department of DefenseArmy
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