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HTLV-III/LAV IS A RECENTLY DESCRIBED HUMAN RETROVIRUS LINKEDBOTH MOLECULAR- AND SEROEPIDEMIOLOGICALLY TO THE CURRENT EPIDEMIC OF AIDS. IT SHOULD BE POSSIBLE NOT ONLY TO INTERFERE WITH VIRAL PROPOGATION IN A CHEMOTHERAPEUTIC MANNER BUT ALSO TO EFFECT IMMUNOPROPHYLAXIS IN THE AT-RISK POPULATION, AS THE SYNDROME HAS AN INFECTIOUS ETIOLOGY. THEAIM OF THIS PROJECT IS TO IDENTIFY VIRALLY ENCODED ANTIGEN ...

THE HUMAN IMMUNE RESPONSE IS GOVERNED BY ORDERED INTERACTIONS BETWEEN FUNCTIONALLY AND PHENOTYPICALLY DISTINCT LYMPOID CELLS (T CELLS AND THEIR SUBSETS, B CELLS) AND MONOCYTES IN THE CONTEXT OF IA-LIKE MOLECULES ENCODED BY THE HLA COMPLEX OF GENES. THUS,THE PRODUCTS OF THESE HLA CLASS II GENES (DP,DQ AND DR) CONTROL THE PROLIFERATIVE RESPONSE OF T CELLS IN MIXED LYMPHOCYTE REACTIONS, ANTIGEN PRESE ...

IN AN EFFORT TO COMPENSATE FOR THE DECLINING SKILL LEVELS OF SHIPYARD WELDERS, THIS PROGRAM RESEARCHES THE FEASIBILITY OF BUILDING AN ADAPTIVE WELD CONTROL SYSTEM USING A RULE-BASED EXPERT SYSTEM AND APPROPRIATE SENSORS. THE SHIPYARD WELDING PROCESS THAT CAN BENEFIT MOST FROM SUCH A CONTROL SYSTEM WILL BE IDENTIFIED. THE KEY DETERMINANTS OF WELD QUALITY AND THE TRANSFER FUNCTIONS THAT RELATE THEM ...

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CRYOCOOLERS AND GAS LIQUEFIERS UTILIZE ISENTHALPIC EXPANSION OF COOLED GAS IN JOULE-THOMSON NOZZLES. TO EFFECTIVELY OPTIMIZE USAGE OF THE COMPRESSED GAS, A VARIABLE GAS MASS FLOW RATE IS NECESSARY. A HIGH FLOW RATE IS REQUIRED INITIALLY WITH A PROGRESSIVE REDUCTION AS THE DESIGN CONDITION IS ATTAINED AND INTERMITTENT FLOW THEREAFTER DEPENDING ON THE LOAD DEMAND. THIS PROJECT INCORPORATES INNOVATIV ...

THE USE OF HIGHLY EXOTHERMIC SELF PROPAGATING INTERMETALLIC REACTIONS IN PROPOSED TO BOND TOGETHER LOW COST ANISTROPIC GRAPHITIC MATERIALS WHICH HAVE SHOWN PROMISE AS LASER RESISTANT MATERIALS DUE TO HIGH REFLECTIVITY AND HIGH HEAT OF VAPORIZATION. IN ADDITION SEVERAL TECHNIQUES ARE PROPOSED IN ORDER TO DEVELOP HIGHLY REFLECTIVE REFRACTORY COATINGS FOR GRAPHITIC SUBSTRATES, AND FINISHED SHAPES OF ...

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A NEW HIGH-FREQUENCY, NONFOULING, FOUR-ELECTRODE, OPEN-CELL CONDUCTIVITY SENSOR FOR OCEANIC USE IS PROPOSED. THIS SENSOR IS TO REPLACE THE COMMONLY USED CONDUCTIVITY CELL MADE BY N. BROWN INSTRUMENT SYSTEM. THE NEW SENSOR WILL BE DESIGNED TO MINIMIZE OR ELIMINATE PROBLEMS ASSOCIATED WITH N. BROWN CONDUCTIVITY CELL. SOME STRINGENT DESIGN CRITERIA ARE SET FOR THE NEW CONDUCTIVITY SENSOR: 1. THE SENS ...

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IN VITRO CYTOGENETIC TESTS TO EVALUATE THE GENETIC HAZARDS OF CHEMICALS ARE INCREASING IN IMPORTANCE FOR PREDICTING IN VIVO EFFECTS. IN PARTICULAR, STUDIES HAVE DEMONSTRATED (1) THE RELEVANCE OF CHROMOSOMAL MUTATION TO INHERITANCE IN GERMCELLS; (2) THAT SPECIFIC CHROMOSOMAL DEFECTS ARE ASSOCIATED WITH MOST NEOPLASIAS; AND (3) THAT CHROMOSOMAL REARRANGEMENTMAY PLAY A ROLE IN ONCOGENE ACTIVATION. HO ...