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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 196161 - 196170 of 207727 results
  1. Technology Assisted Treatment for Trichotillomania

    SBC: HABITAWARE, INC.            Topic: 102

    Abstract Significance: Trichotillomania (TTM), characterized by repeated pulling of one’s hair to the point of hair loss or thinning, produces impairment in physical, social, psychological and occupational functioning. While evidenced-based treatments (EBTs, i.e. self-monitoring, stimulus control, and Habit Reversal Training (HRT)) do exist, access is limited due to lack of trained treatment pro ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Improving influenza vaccines through wastewater-based macro-scale strain surveillance

    SBC: GT MOLECULAR, INC.            Topic: NIAID

    ABSTRACT Influenza infects 9 to 45 million people in the United States each year and results in 300,000 to 500,000 deaths worldwide. Vaccination is the foundation of the global response to control and reduce the spread of Influenza; however, seasonal influenza vaccine efficacy ranged from non-statistically significant to 60% between 2011 and 2019.Vaccine efficacy is largely contingent upon properl ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  3. Tau mislocalization assay to screen AD therapeutics using compartmentalized chips

    SBC: Xona Microfluidics, Inc.            Topic: R

    PROJECT SUMMARY: Neurofibrillary tangles, a hallmark of Alzheimer's disease (AD), are formed following tau dissociation from microtubules and mislocalization to the somatodendritic compartment of affected neurons. Pathological tau is then released from affected neurons and spreads trans-synaptically eventually leading to cell death. Preventing the initial mislocalization of intracellular tau withi ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. mRNA Delivery of a Panel of Single-Domain Antibodies for Combinatorial Deciphering of Therapeutic Targets for Covid-19 Related Cytokine Release Syndrome

    SBC: ONCOTRAP INC            Topic: NIAID

    Project Summary/Abstract Severe COVID-19 patients who develop acute respiratory distress syndrome (ARDS) and multiple organ failures share a hyperinflammatory cytokine/chemokine expression profile. This clinical observation resembles the cytokine release syndrome (CRS) which was the leading cause of mortality in patients infected with SARS-CoV and MERS-CoV. US FDA have fast-tracked dozens of clini ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. iOP-Connect System for Long-Term Continuous Monitoring of Glaucoma Therapy by means of an Implantable Autonomous Intraocular Pressure Sensor

    SBC: Injectsense, Inc.            Topic: NEI

    Project Summary The iOP-Connect system is a medical device that incorporates novel microelectronics technology and data science to revolutionize glaucoma patient care by enabling long-term continuous monitoring of glaucoma therapy effectiveness. The iOP-Connect is the only continuous IOP-monitoring system technology to receive a Breakthrough Device Program designation from FDA. The goal of this Ph ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  6. ELIMINATION OF AIRBORNE VOLATILE COMPOUNDS THROUGH INCORPORATION OF ADVANCED 3D NANOSTRUCTURED CATALYTIC COATINGS IN ADSORPTION/DECOMPOSITION AIR PURIFICATION SYSTEMS

    SBC: METALMARK INNOVATIONS, PBC            Topic: R

    Project Summary / Abstract Every year, eight million premature deaths and $5 trillion of societal costs are linked to air pollution. According to the US EPA, indoor air quality (IAQ) is often two to five times worse than outdoor air, which is especially alarming since we spend 90% of our time indoors. In fact, poor IAQ accounts for 48% of air pollution-related deaths. Submicron-scale pollutants, ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Limbix Spark: a CBT-based mobile intervention for adolescent depression

    SBC: Limbix Health, Inc.            Topic: 104

    Project Abstract Depression affects more than 3.2 million adolescents in the USA, with rising incidence and suicide rates that carry devastating personal, societal, and economic impact. Effective care for adolescent depression is limited due to lack of access, shortage of providers, long waitlists, stigma, and ineffective or partially effective pharmacological options. Many adolescents with depres ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Phosphosulindac for dry eye

    SBC: Apis Therapeutics, LLC            Topic: N

    ABSTRACT The treatment of dry eye disease (DED) has been hampered by weak agents, significant side effects and high cost. The pathophysiological hallmark of DED that unifies its diverse etiologies is inflammation of the ocular surface that accounts for its clinical manifestations. The optimal treatment of DED must provide strong efficacy; topical analgesia; safety; convenient dosing; and low cost. ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Digital Transformation to Reduce Social Isolation and Improve the Engagement, Care, and Support of Individuals Living with Alzheimer's Disease and Related Dementias: Diversity Supplement

    SBC: DETERMINED HEALTH INC.            Topic: NIA

    Social isolation and loneliness accelerate cognitive and functional decline, increase premature mortality, and significantly reduce quality of life in older Americans. Social isolation and loneliness are associated with $6.7 billion in additional Medicare spending annually, and are key drivers of inefficient, ineffective, and costly care. Individuals living with Alzheimer’s disease and related d ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Ultrasensitive multiomic platform using epitope-targeted DNA methylation mapping

    SBC: Epicypher, Inc.            Topic: NHGRI

    Candidate Eligibility StatementThe goal of this diversity supplement application is to provide career development support for Dr. Allison Hickman, a bioinformatician who aspires to (and with support could perform) leadership roles in commercial science. Women have been under-represented in science leadership, particularly in the field of bioinformatics, and this award would formally address the is ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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