Award Data

DESCRIPTION (provided by applicant): Monoclonal antibodies exhibit high specificity for target molecules and for that reason have been successfully utilized as therapeutic and diagnostic agents. The sequence of amino acids comprising the primary structureof an antibody is largely responsible for its binding preference and efficacy. Therefore, antibody sequencing is a central requirement for the de ...

DESCRIPTION provided by applicant Antibodies are ideal drug candidates due to high specificity for target molecules Monoclonal antibodies represent one of the fastest growing segments of the drug market however recent attention has focused on polyclonal antibodies and monoclonal mixtures to reduce the opportunity for a disease to become drug resistant Polyclonal antibodies sampled from dise ...

A procedure and supporting computer code for the prediction of noise that radiates from small, vertical lift UAV aircraft is proposed. The resulting building block procedure is theoretically based but is verified experimentally at several output stages. Noise source models for rotors, lift-fans, engines etc. are developed and validated through specially designed experiments and stored in a compo ...

Navy aircraft employ components that are contoured for aerodynamic performance and made of composite sandwich structures for high strength-to-weight ratio. Many of these components presently use honeycomb cores surrounded by thin high strength face sheets. While honeycomb is used extensively, it can be difficult to form to contoured shapes, must be spliced to reinforce high stress locations, provi ...

This project proposes the development and integration of two different software models for the same object; a high fidelity and a low fidelity model, which can be interchanged within the DARPA Weapon Generation Tool. Using validated engineering models in Distributed Simulation experiments provides users with a higher degree of realism in the cures that are produced by the simulation. Not all model ...

Opterus Research and Development, Inc. proposes to develop and validate multi-scale thin-ply High Strain Composites (HSCs) constitutive modeling tools for incorporation into commercial finite element analysis codes. The constitutive models will capture the time-temperature-load-deformation viscoelastic characteristics common to HSCs as well as the yielding or permanent deformation associated with ...

Opterus Research and Development, Inc. proposes to develop and validate multi-scale thin-ply High Strain Composites (HSCs) constitutive modeling tools for incorporation into commercial finite element analysis codes. The constitutive models will capture the time-temperature-load-deformation viscoelastic characteristics common to HSCs as well as the yielding or permanent deformation associated with ...

The overall objective of this SBIR effort is to develop and verify an improved mathematical model of human gravito-inertial spatial orientation (SO) that estimates perceptions resulting from the integration of orientation/motion cues provided by visual, auditory, vestibular, and somatosensory senses, especially those cues existing in the aerospace environment. An advanced SO modeling system that i ...

Spin-polarized electrons are required by several projects relevant to the U.S. Department of Energy mission. More- over, many next generation applications require generation of spin-polarized electron beams with high bunch charge (up to 50 nC) and/or high average current (50 mA). Currently, GaAs-related photocathodes, based on different designs, are used to emit electron beams with high polarizati ...

Plasma assisted processing techniques are widely used in many industries to synthesize materials at low process temperatures. Stringent precision requirements for devices and the demand for low cost manufacturing techniques emphasize the need for optimizing plasma reactors. Numerical simulation offers a quick and inexpensive alternative/supplement (to hardware experimentation) for designing new an ...