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ARTIFICIAL SEEDS PROVIDE A CLONAL SYSTEM TO PROPAGATE ELITE AND IMPROVED GERMPLASM OF SEED CORPS SUCH AS ALFALFA, WITH OUT THE PREREQUISITE OF MEIOTIC RECOMBINATION. ALTHOUGH CL CLONAL PROPAGATION HAS BEEN USED FOR VEGETATIVELY-PROPAGATEDCROPS FOR MILLENNIA, SUCH PROPAGATION HAS NOT BEEN AVAILABLEFOR SEED CROPS PRIOR TO THE DISCOVERY OF PLANT TISSUE C CULTURE TECHNIQUES. THE FIRST STEPS FOR CREATI ...

THIS PROPOSAL DESCRIBES THE DEVELOPMENT OF A MODERN DIAGNOSTIC TEST AND THERAPY FOR INFANT RESPIRATORY DISTRESS SYNDROME (RDS). RDS IS THE LEADING CAUSE OF NEONATE MORTALITY AND MORBIDITY. IT IS DUE TO INADEQUATE LEVELS OF LUNG SURFACTANT, A LIPID-PROTEIN COMPLEX ESSENTIAL FOR LUNG INFLATION. CURRENT DIAGNOSTIC ASSAYS ARE BASED ON THE LIPID COMPONENT OF SURFACTANT AND ARE UNRELIABLE. WE PROPOSE TO ...

HYPERTENSION IS A SERIOUS AND WIDESPREAD MEDICAL PROBLEM. WHILE A VARIETY OF APPROACHES CURRENTLY EXIST FOR CONTROLLING HYPERTENSION, MANY PATIENTS COULD BENEFIT FROM NEW ANTIHYPERTENSIVE DRUGS THAT ARE MORE SPECIFIC THAN THOSE PRESENTLY AVAILABLE. RENIN INHIBITORS CONSTITUTE A POTENTIAL CLASS OF HIGHLY ACTIVE YET SPECIFIC ANTIHYPERTENSIVE AGENTS. ONE IMPEDIMENT TO THE DESIGN OF USEFUL RENIN INHIB ...

INFLAMMATORY DISORDERS ACCOUNT FOR A SIGNIFICANT PERCENTAGE OF DEBILITATING DISEASES. IT IS NOW APPARENT THAT CENTRAL TO THE THERAPEUTIC CONTROL OF THE INFLAMMATORY REACTION IS THE REGULATION OF THE PHOSPHOLIPID METABOLITES, THE EICOSANOIDS. IN MOST TISSUES THE SYNTHESIS OF THE EICOSANOIDS IS LIMITED BY THE AVAILABILITY OF ARACHIDONIC ACID (AA) WHICH IS FIRST LIBERATED FROM MEMBRANE PHOSPHOLIPIDS ...

RESEARCHERS WILL DESCRIBE STUDIES DESIGNED TO DEVELOP SPECIFIC DIAGNOSTIC ASSAYS OF ATRIAL NATRIURETIC FACTOR AND ITS METABOLITES. SUCH ASSAYS ARE CURRENTLY NOT AVAILABLE BUT ARE REQUIRED FOR A COMPLETE UNDERSTANDING OF ATRIAL NATRIURETIC FACTOR IN THE REGULATION OF BLOOD PRESSURE. THIS STUDY INVOLVES THE PREPARATION AND USE OF MONOCLONAL ANTIBODIES TO DEFINED REGIONS OF THE PEPTIDE. THE RADIO AND ...

THE GOAL OF THIS RESEARCH IS THE DEVELOPMENT OF RECOMBINANT CONTRACEPTIVE VACCINES, USING HUMAN CHORIONIC GONADOTROPIN (HCG) CARBOXY-TERMINAL PEPTIDE (CTP) AS A MODEL SYSTEM. TO OVERCOME CURRENT CONJUGATION PROBLEMS, GENES ENCODING CON- JUGATED HCG CTP FUSED POLY-PROTEINS CAN BE SYNTHESIZED. TO OVERCOME CURRENT ADJUVANT PROBLEMS, THESE PROTEINS WILL BE DELIVERED AS A RECOMBINANT VACCINIA VACCINE. ...

THE GOAL OF THIS RESEARCH IS TO PRODUCE EFFECTIVE STABLE MICROEMULSIONS OF LIPOSOLUBLE VITAMINS FOR INTRAVENOUS DELIVERY. THE ADMINISTRATION OF FAT-SOLUBLE VITAMINS BECOMES A MEDICAL PROBLEM WHEN DEFICIENCIES IN THESE SUBSTANCES ARE DISPLAYED BY SUBJECTS WITH MALABSORPTION SYNDROME. LIPOSOLUBLE VITAMIN DEFICIENCY IN HUMANS IS MOST OFTEN ENCOUNTERED IN PREMATURE INFANTS AND IN ADULTS OR CHILDREN HA ...

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GROUND WATER AT SOME AIR FORCE FACILITIES HAS BECOME CONTAMINATED WITH JET FUEL. THIS MATERIAL IS COMPRISED OF OVER 200 COMPONENTS, MOST OF WHICH ARE STRAIGHT AND BRANCHED-CHAIN HYDROCARBONS HAVING BETWEEN FIVE AND FIFTEEN CARBON ATOMS. SINCE ORGANISMS KNOWN TO DEGRADE SIMILAR COMPOUNDS ARE WIDESPREAD IN SOIL, IN SITU BIOREMEDIATION IS CONSIDERED A PROMISING APPROACH. THIS PROCESS CONSISTS OF ADDI ...