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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 196181 - 196190 of 207725 results
  1. Rapid, Very Low Cost, Automated DNA Purification Device

    SBC: MacConnell Research Corporation            Topic: NIGMS

    DESCRIPTION (provided by applicant): This work will create innovative products that allow rapid, low cost, automated, multi- sample genomic DNA purification from many sample types and concentrations. The novel technology that we will further develop and validate in Phase I, uses disposable cassette device and low cost processing cradle to automatically purify DNA by self-contained, semi-dry electr ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  2. Development of Specific Gene Silencing Methods and Reagents

    SBC: BOSTON BIOMEDICAL, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): RNA interference (RNAi), a potent and selective gene silencing mechanism, has revolutionized the field of biological science. The ability of RNAi to specifically down-regulate the expression of any gene has had a profound impact on the study of gene function, and holds great promise for in vivo functional genomics. The current paradigm for inducing RNAi in mam ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  3. A Novel System for Mass Production of iPS Cells

    SBC: PRIMORIGEN BIOSCIENCES INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Primorigen Biosciences LLC SBIR Project Abstract Primorigen will use SBIR funds to develop and validate a microcarrier-based cell culture system for selection, scale-up and feeder-free mass production of iPS cells, based on Primorigen's proprietary pluripotent stem cell attachment factor (StemCadhere ) for direct physical selection and propagation of iPSC. ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  4. Efficient double hybrid density functional theory algorithms for conformational a

    SBC: Q-CHEM INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Double hybrid (DH) density functionals are one of the most promising new developments in quantum mechanical methods for simulating biomolecules. DH functionals have been reported to yield much more accurate intermolecular interaction energies than previous generation functionals. They are therefore on the threshold of becoming widely used. However, there are st ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  5. Multiplexed Nucleic Acid Assays

    SBC: PROGNOSYS BIOSCIENCES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): New technologies are needed to enable the multiplexed analysis of gene expression in many samples in parallel. This would enable the generation of high-resolution maps of gene expression of the mammalian brain, as wellas other complex tissues. This proposal aims to develop novel technology to enable applications of this type. It is suited to analyzing complex a ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a novel assay for the analysis of newly synthesized RNA

    SBC: BIOO SCIENTIFIC CORPORATION            Topic: NIGMS

    DESCRIPTION (provided by applicant): While changes in mRNA decay rates account for approximately 50% of the regulation of gene expression in the cell, an assay to accurately and reliably measure mRNA half lives is currently not available. In particular, the deficiency of reliable commercial kits which enable the average biomedical research lab to effectively investigate mRNA decay rates is signifi ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  7. Development of an Instrument to Determine Protein Stability at any Desired Temper

    SBC: AVIA BIOSYSTEMS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Protein therapeutics is the fastest growing segment in the biotechnology and pharmaceutical industry. Protein therapeutics includes monoclonal antibodies, recombinant proteins, chimeric proteins and other protein receptor constructs. It is expected to reach over 70 billion in sales by 2010. A major hurdle in the development of proteins as pharmaceutical drugs ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  8. Biodegradable, hyaluronic acid-based microcarriers for mesenchymal stem cell prop

    SBC: BioTime, Inc.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The emergence of human mesenchymal stem cell (hMSC)-based therapies requires the growth of a large number of viable, clinical grade hMSC for transplantation and their subsequent delivery into a specific site. Current methods for both large-scale growth on the surface of tissue culture plastic and for subsequent cell harvest using trypsin are both inefficient fo ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  9. Droplet-based artificial membrane technology for high throughput cell-free ion ch

    SBC: LIBREDE            Topic: NIGMS

    DESCRIPTION (provided by applicant): Ion channels pharmaceutical discovery and safety screening is slow and expensive and as a result, there are currently no high quality, high throughput assays for ion channel screening. Librede Inc. is developing alternative cell-free technologies for ion channel measurement which have the potential for higher throughput and lower cost. In preliminary work, we ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  10. Development of Pluripotent Amniotic Stem Cell Banks for Disease Modeling

    SBC: TECHTOWN VENTURES,, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Direct reprogramming of somatic cells with the transcription factors Oct4 (also called Pou5f1), Sox2, Klf4 and Myc1 yields induced Pluripotent Stem (iPS) cells with marked similarity to Embryonic Stem (ES) cells. When the source of the cells is patients affected by various disorders iPS cells promise to be excellent models to study the gradual pathogenesis ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
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