Award Data

DESCRIPTION (provided by applicant): The ultimate goal of this application is to develop a novel ex vivo purging method using myxoma virus (MYXV), a rabbit-specific poxvirus, to improve the clinical outcomes in treatment of multiple myeloma (MM). MM is aclonal plasma cell malignancy that has to date resisted essentially all therapeutic strategies. Currently, the standard of care for patients wit ...

THE LONG-TERM GOAL IS TO APPLY NEW TECHNOLOGIES TO DEVELOPMENT OF AN INSTRUMENT, THE CORNEAL SCANNER, THAT WILL EASILY MEASURE THE CENTRAL AND PERIPHERAL CURVATURES OF THE CORNEA AND NOT BE AFFECTED BY DISTORTION OF THE CORNEA. CURRENT INSTRUMENTS CAN ONLY MEASURE THE CENTRAL 25% OF THE CORNEA AND CANNOT BE EFFECTIVELY USED IF THE CORNEA IS DISTORTED. HAVING AN INSTRUMENT TO MEASURE THE ENTIRE COR ...

THE LONG RANGE OBJECTIVE OF THE PROPOSED RESEARCH IS TO APPLY IMAGE PROCESSING TECHNOLOGY TO THE DEVELOPMENT OF AN AUTOMATED OPHTHALMIC INSTRUMENT THAT WILL RAPIDLY MEASURE THE ALIGNMENT OF BOTH EYES IN PRIMARY GAZE AND QUANTITATIVELY DETERMINE PHORIAS AND TROPIAS FOR THE OPHTHALMOLOGIST, THE OPTOMETRIST AND THE PEDIATRICIAN AS PART OF THE ROUTINE OFFICE EYE EXAMINATION OF CHILDREN AND ADULTS. WIT ...

WE PROPOSE TO BUILD A COMPUTER-GRAPHICS, PHASE-DIFFERENCE, CRT HAPLOSCOPE. THIS WILL BE A PROGRAMMABLE, FLEXIBLE, STEREOSCOPIC DISPLAY SYSTEM USEFUL FOR: 1. RESEARCH IN BINOCULAR VISION, STRABISMUS, AND AMBLYOPIA; 2. CLINICAL SCREENING AND MEASUREMENT OF STRABISMUS AND AMBLYOPIA; AND 3. CLINICAL ORTHOPTICS. THE SYSTEM IS BUILT PRIMARILY FROM 'OFF-THE-SHELF' COMPONENTS TO REDUCE THE COST. LIQUID-CR ...

DESCRIPTION (provided by applicant): The importance of the early detection and correction of eye problems in children is widely recognized. However, a substantial percentage of children ages five and under are not screened for eye problems, as acknowledged by the major vision-related professional organizations. A specific objective of the Department of Health and Human Services Healthy People 2010 ...

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DESCRIPTION (provided by applicant): The Fontan procedure is currently standard care for patients with complex single ventricle congenital heart defects. The Fontan procedure involves the creation of a cavopulmonary (CP) shunt connecting the inferior and superior vena cava (IVC and SVC) directly to the right pulmonary artery (RPA), diverting total venous return from the IVC/SVC directly to the PA ...

DESCRIPTION (provided by applicant): Left ventricular assist devices (LVADs) are increasingly applied to treat advanced heart failure, demonstrating improvement of morbidity/mortality and quality of life. Right heart failure (RHF) affects up to 40% of LVADpatients and significantly contributes to their morbidity and mortality. One third of them require right ventricular assist device (RVAD) which ...

DESCRIPTION (provided by applicant): Left ventricular assist device (LVAD) support allows the neonate with congenital heart disease or cardiomyopathy to grow to a larger body weight that is more feasible for complex surgical correction or heart transplant.A paracorporeal LVAD, the Berlin heart ExCor, is FDA-approved for pediatric application. Although this device is outside the body, the outflow g ...

Aircraft wing skins contain thousands of fastener holes, which can act as crack initiation sites for structures under severe fatigue conditions. Major cracks have developed around aircraft fastener holes, which can propagate into larger cracks and possible result in catastrophic failure. Compressive residual stresses have been shown to improve fatigue performance for a variety of applications. Cur ...