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JMSI Inc. and the University of California, Davis, shall develop a methodology they call - Intelligent In-Situ Feature Detection, Tracking and Visualization For Turbulent Flow Simulations. This method utilizes a Python-based framework that enables any Python wrapped flow solver to share, without redundant memory penalties, pertinent data structures with intelligent feature detection-tracking tool ...

PRIMARY AROMATIC AMINES THAT WERE IMPLICATED IN BLADDER CARCINOGENESIS (BASED ON THE EPIDEMIOLOGICAL DATA WITH WORKERS IN RUBBER AND DYE INDUSTRIES) EXHIBIT SEX AND SPECIES SPECIFICITY. URINARY AND BLADDER CANCER IS MORE PREVALENT IN CAUCASIAN MALES. AROMATIC AMINES ARE MORE CARCINOGENIC IN DOGS AND LESS ACTIVE IN RODENTS, WHICH CORRELATES TO THE RELATIVE METABOLIC ACTIVITIES IN RESPECTIVE TISSUES ...

PHASE I RESEARCH WILL EXAMINE THE RELATIONSHIP BETWEEN CYTOTOXICITY, MUTAGENICITY, AND CLASTOGENICITY BY USING A NUMBER OF BIOCHEMICAL TECHNIQUES: DNA ADDUCT FORMATION, DNA/DNA AND DNA/PROTEIN CROSS-LINKING, DNA STRAND BREAKS, AND SEQUENCE ANALYSIS OF DNA. A SELECT GROUP OF CHEMICAL AGENTS WILL BE EVALUATED FOR MUTAGENIC ACTIVITY IN THE MOUSELYMPHOMA (L5178Y/TK+/-) ASSAY SYSTEM BY SELECTING FOR TR ...

DUE TO THE SPEED AND SIMPLICITY INVOLVED IN MICRONUCLEI (MN) IDENTIFICATION, MN ANALYSIS HAS BECOME INCREASINGLY USED AS A SENSITIVE, YET LESS EXPENSIVE AND TIME CONSUMING ALTERNATIVE TO CLASSICAL METAPHASE ANALYSIS. THE SCORING OF MN IS ONE OF THE FEW METHODS CURRENTLY AVAILABLE FOR THE DETECTION OF ANEUPLOID-RELATED PROCESSES. ALTHOUGH SEVERAL MN ASSAYS HAVE BEEN DEVELOPED, THE MOST WIDELY USED ...

SENSITIVE, REPRODUCIBLE AND COST-EFFECTIVE METHODS ARE NEEDED TO EVALUATE THE POTENTIAL OF CHEMICALS TO INDUCE DNA DAMAGE IN MALE AND ESPECIALLY, FEMALE GERM CELLS.THE SINGLE CELL GEL (SCG) ELECTROPHORESIS ASSAY IS A SENSITIVE METHOD FOR DETECTING SINGLE STRAND DNA BREAKS AND ALKALI-LIABILE SITES IN THE DNA OF INDIVIDUAL CELLS. USING SAMPLES CONSISTING OF A FEW THOUSAND CELLS, THIS ASSAY CAN PROVI ...

FOR THE BIOMONITORING OF DNA DAMAGE IN HUMANS POTENTIALLY EXPOSED TO GENOTOXIC AGENTS, AN OPTIMAL METHOD SHOULD BE CAPABLE OF DETECTING MANY CLASSES OF DNA DAMAGE IN A VARIETY OF CELL TYPES, SHOULD PROVIDE DATA AT THE LEVEL OF THE INDIVIDUAL CELL, AND SHOULD BE SENSITIVE, RAPID AND COST EFFECTIVE. AN ALKALINE MICROGEL ELECTROPHORESIS ASSAY HAS BEEN DEVELOPED WHICH APPEARS TO FULFILL THESE GOALS. T ...

The introduction and increasing use of several man-made and synthetic fibers have raisedconcern over their possible health effects in view of their similarity to asbestos, a known carcinogen.Animal studies have clearly indicated the carcinogenic effects of asbestos fibers, Furthermore, theeffects of asbestos on cultured cells include cytotoxicity and the induction of chromosome aberrationsand cell ...

For the biomonitoring of DNA damage in aquatic species exposed to genotoxic agents, an optimal methbe capable of detecting many classes of DNA damage in a variety of cell types, should provide data aindividual cell, should be adaptable to field studies, and should be sensitive, rapid, and cost effeelectrophoresis assay has been developed which appears to fulfill these criteria. The Single Cell Gei ...