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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 196251 - 196260 of 207728 results
  1. Therapeutic antibodies for treating chemotherapy induced peripheral neuropathic pain

    SBC: ABALONE BIO, INC.            Topic: NCI

    ABSTRACT Chemotherapy-induced peripheral neuropathy (CIPN) is an often long-lasting neurological condition that arises frequently in cancer patients who receive broadly used chemotherapies such as taxanes. CIPN causes abnormal pain and other symptoms that can limit chemotherapy dosage and significantly impact quality of life for years. There are no drugs that prevent CIPN or treat it well. Duloxet ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a Bariatric Mannequin System to Enable Realistic Examination Simulations of Obese Patients

    SBC: INNOVATIVE DESIGN LABS INC            Topic: 300

    Project Summary/Abstract The proposed project focuses on creating a bariatric mannequin simulator to educate healthcare students on proper techniques specific and specialized to bariatric patient care. Significance: Obesity is one of the world’s most significant and growing health problems. More than 2 in 3 adults are overweight or have obesity and obese patients have a greater likelihood of req ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  3. Assistive ExoSkeleton and ExoTendon System for Increased Return of Limb Function after Diabetic Foot Ulcer

    SBC: RESULTS GROUP, LLC            Topic: 600

    Project Summary / Abstract Relatedness to Mission: Application aligns with 2019 Supplemental Goals for both NINR and NIA.: NINR: Assistive…devices that can… improve quality of life for individuals with chronic diseases/conditions NIA: Development of technologies/robotics to assist in the improvement of physical function and mobility in older persons prior to (pre-habilitation) or following (re ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  4. Development of RespiraClear for targeted mucosal treatment of RSV infections

    SBC: MUCOMMUNE, LLC            Topic: NIAID

    Abstract Project Summary Respiratory Syncytial Virus (RSV) is the leading cause of viral death in infants and young children, and a major cause of respiratory illness in immune compromised adults and the elderly. Unfortunately, there is currently no vaccine or effective therapy available for RSV. Synagis, a monthly intramuscular injection of the monoclonal antibody (mAb) palivizumab, is the only F ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  5. Treatment of Restless Legs Syndrome through non-invasive peripheral nerve stimulation

    SBC: NOCTRIX HEALTH, INC.            Topic: NINDS

    Restless Legs Syndrome (RLS) affects the ability to fall and stay asleep for more than 10% of the western adult population. In the median age group of 50-79 years alone, more than 25 million adults are seeking treatment for RLS, making it the second most common sleep disorder in the world. The severe leg sensations of RLS are most prevalent at night, thus leading to sleep deprivation and its downs ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  6. ShRNA-Based Targeting of mAKAPβ in Heart Failure

    SBC: CARDIAC RSK3 INHIBITORS, LLC            Topic: NHLBI

    Pathological cardiac remodeling constitutes a common pathway to heart failure in disease. Despite current pharmacologic therapy and other advances that attenuate remodeling, mortality due to heart failure remains high. New, more effective therapeutic options are desperately needed in an increasing patient population to improve both the survival and quality of life for patients with or susceptible ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  7. Micronized salsalate in a parenteral formulation is a safe and effective analgesic for acute postoperative pain management

    SBC: RH NANOPHARMACEUTICALS L.L.C.            Topic: 102

    SUMMARY: The White House has initiated an aggressive campaign to combat the current opioid crisis that is affecting all levels of the American way of life. The opioid crisis has emerged from multiple fronts. Among these various fronts, the continued use of opioids in the post-operative area is a growing addiction risk. Current post- operative pain management utilizes a multimodal pain management s ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  8. Rat and Canine Microphysiological Systems of the Kidney Proximal Tubule for Chemical Toxicity Screening

    SBC: Nortis, Inc.            Topic: R

    Project Summary Humans are constantly exposed to a variety of chemicals via food, household products, medicines, and the environment. The kidney is particularly susceptible to chemical damage; drug-induced nephrotoxicity is a major health concern that contributes to 25% of all cases of severe acute kidney failure. Nephrotoxicity is also a significant problem in drug development; it is a major caus ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  9. Microneedle Based Targeted Allergen Specific Immunotherapy for Treatment of Peanut Allergies

    SBC: MOONLIGHT THERAPEUTICS, INC.            Topic: NIAID

    Microneedle Based Targeted Allergen Specific Immunotherapy for Treatment of Peanut Allergies Food allergies affect 15 million people in the USA and 17 million in Europe. Six million children, roughly 1 in 13, in the USA have at least one food allergy; this equates to at least 1 in every classroom. Currently, there are no approved therapies for food allergies anywhere in the world. Food allergies a ...

    STTR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  10. Analytical validation of a biochemical test for alpha-synuclein aggregates in biological fluids for the diagnosis of Parkinson's Disease

    SBC: Amprion, Inc.            Topic: 105

    PROJECT SUMMARYMisfolded protein aggregates are toxic supramolecular proteinaceous conglomerates that self- replicate in the host, causing damage to surrounding tissue. Several of these protein aggregates are strongly associated with neurodegenerative diseases, such as the prion protein in prion diseases, Amyloid β and tau in Alzheimer’s (AD), TDP-34 in amyotrophic lateral sclerosis (ALS) and F ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
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