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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 196281 - 196290 of 207712 results
  1. AGR2-superantigen vaccine conjugate for the treatment of pancreaticductal adenocarcinoma

    SBC: LEUKOGENE THERAPEUTICS INC            Topic: NCI

    Project Summary/Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest forms of cancer. Poor survival rates are largely due to the late stage at which PDAC is diagnosed and a lack of effective targeted therapies. While the field of immunotherapy has significantly increased overall survival in some malignancies, they have not translated to PDAC. The long-term goal of this research ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Bifunctional Small Molecule for the Treatment of Alcohol Use Disorder

    SBC: DINA PHARMA INC            Topic: 150

    SUMMARYAlcohol use disorder (AUD) is a common problem that affects over 14 million Americans at a cost of $250B and yet less than 10% of the afflicted population are treated with medication that is known to be effective. The current pandemic and the resulting social isolation have resulted in a significant increase in the prevalence and severity of this condition. However, currently available trea ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  3. Brief Personalized Feedback Intervention for Latinx Hazardous Drinkers: A Community-Based Intervention

    SBC: HEALTH BEHAVIOR SOLUTIONS INC            Topic: 450

    PROJECT SUMMARY/ABSTRACT Despite being one of the largest and fastest-growing demographics in the United States (US), Latinx persons experience striking health disparities, particularly in terms of hazardous drinking and co-occurring elevated anxiety. The co-occurrence of these risk factors contributes to worse physical/mental health outcomes among Latinx individuals. Few interventions to date hav ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. A Novel Bacterially-derived Product to Enhance Immunity and Response to Immune Checkpoint Therapy

    SBC: AUMENTA BIOSCIENCES, INC.            Topic: NIAID

    Abstract Aumenta is developing a product derived from two commensal bacterial species for use as an innovative immunologic therapy. The product is designed to augment multiple arms of the immune system, offering a safe, novel and innovative therapy for unmet needs in treating infectious disease (e.g. fungal infections) and enhancing the bodyandapos;s response to immuno-oncology therapies (e.g. imm ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Tolerability and Potency of Sequential and Repeated AAV Corneal Gene Therapy

    SBC: RAINBIO, INC.            Topic: NEI

    Abstract Mucopolysaccharidosis I (MPS I) is an autosomal recessive monogenetic disorder caused by mutations in the gene encoding alpha-L-iduronidase (IDUA), a ubiquitous enzyme that breaks down large sugar molecules called glycosaminoglycans (GAGs). In the absence of IDUA, intra- and extra-cellular GAG accumulation results in enlarged cells/organs resulting in a multifactorial and potentially leth ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Development and characterization of HIV-1 Tat degraders

    SBC: Thimble Therapeutics Inc            Topic: NIAID

    AbstractDespite effective antiretroviral therapy (ART), latent proviruses can reinitiate viral production upon cell stimulation or treatment interruption. The viral Tat protein enhances transcript elongation from the HIV-1 promoter, controlling the switch between latency and active viral production. The block-and-lock functional cure aims at the transcriptional silencing of the viral reservoir, re ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Momitor: Wearable Technology for Early Detection of Postpartum Hemorrhage

    SBC: Vasowatch LLC            Topic: NHLBI

    Abstract: Postpartum hemorrhage (PPH) is the leading cause of maternal death worldwide and disproportionately affects minority populations. PPH is defined as a large loss of blood within 24 hours of birth. If detected early enough, effective clinical management solutions exist that significantly reduce mortality. Current standard of care for detecting PPH rely on vital sign monitoring and visually ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Protease Stable N-Terminally Modified Therapeutic Peptides

    SBC: VELUM INC            Topic: NIDDK

    PROJECT SUMMARY Peptide therapeutics combine high potency and selectivity, and engender fewer side effects than traditional small molecules. This has fueled interest in peptides filling the gap between ‘biologics’ and small molecules, as peptide-based compounds have key desired properties that are distinct both of the other classes. A major challenge remains to extend the short half-life of na ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Solid State Non-Reciprocal Microwave Devices

    SBC: GONIOTECH LLC            Topic: OSD21C001

    This proposal focuses on developing gyrators, isolators and circulators fabricated from goniopolar materials that have the potential to operate at high-THz frequencies. These non-reciprocal devices are essential components in telecommunications, antennas and quantum computers. The devices will be designed like those built from Hall plates, but with goniopolar materials used, as these avoid the use ...

    STTR Phase I 2022 Department of DefenseOffice of the Secretary of Defense
  10. Non‐reciprocal metasurfaces for photonic integrated circuits

    SBC: NANOHMICS INC            Topic: OSD21C001

    This proposal investigates nonlinear metasurface technology that exploits sharp Fano-resonances to engineer energy and size efficient photonic devices that perform better than the state-of-the art isolators, switches, and modulators. To circumvent the fundamental bounds of performance with single Fano-resonator isolators, this work will demonstrate novel isolators comprising of two stacked Fano-me ...

    STTR Phase I 2022 Department of DefenseOffice of the Secretary of Defense
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