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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 196301 - 196310 of 207712 results
  1. Effect of a semi-synthetic oxysterol drug candidate, Oxy210, on atherosclerosis in a mouse model of NASH

    SBC: Max Biopharma, Inc.            Topic: NHLBI

    ABSTRACT Cardiovascular disease (CVD) remains the leading cause of death in the United States and worldwide. The large majority of CVD-related deaths are the direct result of atherosclerosis and its cardiovascular complications. Atherosclerosis is a chronic inflammatory disease triggered by low density lipoprotein cholesterol (LDL-C), its accumulation and oxidation in the artery wall, and recruitm ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Ultrasensitive, High-Specificity Rapid Test to Support the End-Game of the Global Program to Eliminate Lymphatic Filariasis

    SBC: BIG EYE DIAGNOSTICS INC            Topic: NIAID

    PROJECT SUMMARY / ABSTRACT Here we propose a rapid, field-deployable, cost-effective, highly sensitive and specific lateral flow assay (LFA) that meets all the requirements recently defined by the World Health Organization (WHO) in a target product profile (TPP) for surveillance activities of Lymphatic Filariasis (LF). LF is a disfiguring and debilitating neglected tropical disease that affects 40 ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  3. A HANDS-FREE LUNG AND CARDIOVASCULAR ASSESSMENT DEVICE (LCAD) FOR THE REMOTE CARE OF PATIENTS WITH CHRONIC CARDIOPULMONARY CONDITIONS

    SBC: MDDRIVEN LLC            Topic: NHLBI

    PROJECT SUMMARY The goal of this project is to develop a remote, hands free self-auscultation and electrocardiogram (EKG) device for at home use in the remote monitoring and management of patients suffering from chronic cardiopulmonary conditions. Chronic obstructive pulmonary disease (COPD), congestive heart failure (CHF) and asthma are the most prevalent chronic cardiopulmonary diseases in this ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. Intraoperative Nerve Damage Assessment Using Nerve-Specific Fluorescence Guided Surgery

    SBC: INHERENT TARGETING LLC            Topic: 106

    PROJECT SUMMARY Acute peripheral nerve crush injuries frequently result from closed or open fractures, joint dislocations, and high- energy collisions. Nerve crush, stretch, or transection can lead to functional deficits ranging from numbness to complete motor and sensory function loss, affecting ~1.6M trauma patients annually. Assessment of the degree of injury and the possibility for functional ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. An innovative non-thiazolidinedione pan-PPAR agonist therapeutic for Alcoholic Hepatitis

    SBC: PLEIOGENIX INC            Topic: 999

    PROJECT SUMMARY Alcoholic Hepatitis (AH) is a severe and acute form of alcohol-mediated liver disease, affecting ~34% of heavy alcohol drinkers, and presents a healthcare burden of ~$2.2 billion/yearly. AH sufferers have a short life expectancy, with about ~70% dying in the first six months after presentation. Re-hospitalization occurs in nearly 40% of the patients within 90 days of their first ho ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Nanomaterial Radioisotope Detectors for Intracellular Measurements

    SBC: SCINTILLATION NANOTECHNOLOGIES INC            Topic: 400

    The capability to analyze cellular uptake of physiological and pharmacological compounds with increasing sensitivity and temporal resolution plays a critical role in understanding the underlying molecular pathways involved in human diseases and disorders. Among the most challenging analytes are those present at very low concentrations with high temporal variability, and small molecules lacking moi ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Discovery of Novel Anti-inflammatory, Non-immunosuppressive Molecules forMitigation of Cytokine Storm in COVID-19 Patients

    SBC: OROX BIOSCIENCES INC            Topic: NHLBI

    Project Summary/Abstract The World Health Organization has reported over 216 million confirmed cases of COVID-19 infections and over 4.5 million deaths world-wide as of August 31, 2021. The rapid introduction of this new coronavirus into a previously unexposed (`naive') population has resulted in a pandemic with tragic consequences on a global scale. Although epidemiological data suggests that man ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Multifunctional injectable agent for endoscopic mucosal resection

    SBC: ALEO BME INC            Topic: 300

    Project Summary The global submucosal injection solution market is estimated to be around $3 billion according to the incidence and prevalence rates of medical diagnoses known to be associated with endoscopic mucosal resection/endoscopic submucosal dissection (EMR/ESD), and the market is driven by the need to improve injectability and prolonged submucosal elevation. To date, only three submucosal ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Wastewater data integration and modelling to accurately predict community and organizational outbreaks due to viral pathogens

    SBC: SUPERIOR STATISTICAL RESEARCH LLC            Topic: NIAID

    Project Summary. The COVID-19 pandemic has magnified the need for enhanced ability to accurately anticipate future outbreaks due to novel and endemic viral pathogens. Without systematic surveillance, the ability to head off outbreaks before they occur is challenging: the data from positive human test results is often too late to prevent a major outbreak from occurring, despite substantial lockdown ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Building a pipeline to generate affinity reagents to phosphothreonine epitopes

    SBC: Tango Biosciences Inc.            Topic: 300

    Antibodies are incredibly powerful tools in basic research and clinical testing because they offer exquisite specificity and affinity in detecting proteins of interest in complex mixtures. They have played a particularly useful role in monitoring post-translational modifications, such as phosphorylated threonine resides, which often regulate a protein's biochemical activity and cellular location. ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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