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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 196311 - 196320 of 207726 results
  1. Hypertonic Saline for Cystic Fibrosis

    SBC: Parion Sciences, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Cystic fibrosis (CF) is an autosomal lethal disease characterized that affects ~30,000 individuals in the US. CF lung disease, the major cause of mortality in CF, is caused by dehydration of airway secretions that leads to mucous adhesion, infection and airways inflammation. A simple means to restore hydration and mucous clearance in CF airways is the inhalati ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  2. Silencing cardiac-specific microRNAs to prevent pathological remodeling in conges

    SBC: Virscio Inc            Topic: NHLBI

    DESCRIPTION (provided by applicant): Heart disease remains the primary cause of morbidity and mortality in the industrialized world and continues to incur costs estimated at 30 billion per year, despite detailed understanding of the mechanisms governing cardiac function and contractility. MicroRNAs (miRNAs), a recently discovered family of tiny regulatory RNAs, act as negative regulators of gene ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  3. Intramural drug infusion balloon for preventing vascular restenosis

    SBC: MEDI-SOLVE COATINGS, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Recently, drug coated balloons (DCB) have emerged as a promising alternative for treating stenosed arterial vessels. The demonstrated efficacy of DCB is tempered by the risk of distal arterial embolism, which can resultfrom systemic drug exposure caused by premature dissolution or delamination of the drug coating into the blood stream during catheter insertion ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  4. Home Based Spirometer for Monitoring Lung Transplant Patients

    SBC: Koronis Biomedical Technologies Corp.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Koronis Biomedical Technologies Corporation (KBT) proposes to develop a spirometer device targeted toward the needs of lung transplantation patients. Spirometers are standard care for the management of post-operative lung transplantation patients due to their high sensitivity to decreases in pulmonary function. In this project KBT will develop a spirometer equi ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  5. Therapeutic Small Molecule Modulators of G beta gama Signaling

    SBC: CALIFIA BIO, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): G protein subunits play a central role in G-protein coupled receptor (GPCR)-mediated signal transduction processes. They act as cofactors in the activation of 7TM receptors and play direct roles in signaling to intracellular targets. GPCR signaling is extremely significant from a therapeutic standpoint; indeed, the majority of marketed pharmaceuticals target th ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  6. Laser Catheter for Bronchial Treatment of Severe Asthma

    SBC: Biotex, Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Asthma afflicts as many as 39 million Americans and some 4,000 will die of the disease each this year. The goal of this Phase I SBIR proposal is to design, develop, build, and test a novel, cooled laser catheter for effecting Bronchial Thermoplasty in a safe and efficient manner. Bronchial Thermoplasty is a relatively new term which refers to destruction of the ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  7. Preclinical Development of a Novel and Effective Treatment for Cough

    SBC: Cerecor Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): The mainstays of symptomatic antitussive therapy, dextromethorphan (DXM) and codeine, are no better than placebo in the majority of controlled clinical trials and have high abuse liability. A lack of knowledge regardingthe mechanisms of cough has hindered the discovery of new treatments over the past few decades. Recent discoveries of peripheral cough receptors ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  8. Targeting CaM Kinase II and Oxidative Damage in Allergic Asthma

    SBC: ALLOSTEROS THERAPEUTICS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Asthma is a major public health problem affecting 25 million American adults and children in the US and over 300 million people globally. It is characterized by reversible airflow obstruction due to bronchial smooth muscle contraction and a diseased epithelial cell phenotype of airway hyper-reactivity (AHR) to environmental stimuli, increase in goblet cell, and ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  9. Ex Vivo Fucosylation of Cord Blood with FTVII and Enhanced Hematopoietic Recovery

    SBC: TARGAZYME, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): The three primary sources of hematopoietic stem cells (HSCs) for bone marrow transplant are: mobilized peripheral blood, bone marrow, and umbilical cord. While each source has its individual benefits and limitations, cord blood has seen increased usage over the past decade due to its ready availability from numerous cord blood banks in the US, along with a redu ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  10. Bedside Monitor to Quantify Cardiac Shunt Flow in Newborns and Small Children

    SBC: TRANSONIC SYSTEMS, INC.            Topic: NHLBI

    DESCRIPTION (provided by applicant): There is no current technology for routine measurement of shunt flow (Qp:Qs - ratio of pulmonary to systemic blood flow) in newborns and small children in the intensive care unit (ICU). Current methods either require placement of highly invasive catheter or depend on assumptions, leading to risky and less accurate measurement of shunt flow. Timely and accurate ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
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