List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Humanization of VLR antibodies for therapeutic applications

    SBC: Novab, Inc.            Topic: 102

    DESCRIPTION provided by applicant Currently there is no FDA approved therapeutic antibody capable of depleting long lived plasma cells A plasma cell specific monoclonal antibody could be used to treat plasma cell malignancies multiple myelomas which are fatal and for which there is no effective treatment and antibody mediated autoimmune and severe allergic disease e g systemic lupus e ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Novel probes detecting ROS1,ALK and RET fusions and mutations in NSCLC

    SBC: GENETAG TECHNOLOGY, INC.            Topic: 102

    DESCRIPTION provided by applicant Cancer is one of the leading causes of death worldwide and lung carcinoma is the leading cause of cancer related death Lung cancer is classified histologically as either small cell lung carcinoma SCLC of lung cancers or non small cell lung carcinoma NSCLC of lung cancers Genetic alterations driving NSCLC are known in only of cases an ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Directed Lineage Immunizations for Eliciting Broadly Neutralizing Antibody

    SBC: GEOVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The proposed project Directed Lineage Immunizations for Eliciting Broadly Neutralizing Antibody tests the directed lineage D L approach to HIV vaccination using clade C immunogens With a D L vaccine a series of progressively evolved Env immunogens are used to drive development of a broadly neutralizing antibody bnAb response which is important because ...

    SBIR Phase I 2015 Department of Health and Human Services
  4. Patient-Tailored Selective Laser Melt-Fabricated Plates for Repair of Foot and Ankle Pathology

    SBC: MEDSHAPE, INC.            Topic: NIAMS

    DESCRIPTION provided by applicant The objective of this project is to develop novel patient specific geometrically complex Titanium Ti alloy plates made by additive manufacturing AM also called D printing for foot and ankle applications These plates will offer superior fixation and mechanical performance while minimizing the plate bulk volume Foot and ankle surgeries are common wh ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Shape-Memory Polymer Device for Distraction Enterogenesis to Treat Short Bowel Syndrome

    SBC: MEDSHAPE, INC.            Topic: 300

    DESCRIPTION provided by applicant Short bowel syndrome SBS results in significant morbidity and mortality in children and adults It is a chronic condition that occurs in up to i live births affects at least adults and costs more than $ billion annually in the United States SBS is caused by loss of intestinal length and thus digestive and absorptive capacity as a resu ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. A next-generation spatial light modulator for mapping of neural networks

    SBC: Boulder Nonlinear Systems, Inc.            Topic: NIBIB

    DESCRIPTION provided by applicant Improving our understanding of the fundamental circuitry and dynamics of the brain has far reaching implications for a wide range of fields including mental health computing and the philosophy of the mind To this end one of the critical questions currently facing neuroscientists lies in how brain states and behaviors arise from the activity of ensembles of ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Optimization and Lead Selection of Novel Antimycobacterial Agents

    SBC: CRESTONE, INC.            Topic: 300

    DESCRIPTION provided by applicant The nontuberculous Mycobacteria NTM are a growing public health concern as the number of opportunistic infections increases Although not a reportable disease there is growing epidemiologic evidence to suggest that NTM cause more infections today in the United States than Mycobacterium tuberculosis Mtb yet unlike Mtb there are few dedicated antimicrobial ...

    SBIR Phase II 2015 Department of Health and Human Services
  8. Nurbits: Playing for Success in Neuroscience (Phase II)

    SBC: IS3D LLC            Topic: 999

    DESCRIPTION provided by applicant The NIH Blueprint for Neuroscience Research identified a need for novel products that engage students in learning neuroscience In Phase I IS D tested the feasibility of Nurbits a videogame in which students apply neuroscience principles to solve puzzles and make music The research team determined that Nurbits was effective in engaging students teachers wer ...

    SBIR Phase II 2015 Department of Health and Human Services
  9. Novel adjuvant therapy for triple negative breast cancer

    SBC: JYANT Technologies, Inc.            Topic: 102

    DESCRIPTION provided by applicant Triple negative breast cancer TNBC is very difficult to treat and has no specific targeted therapies Chemotherapies used to treat this disease have many undesirable side effects and patients eventually relapse as a result of chemoresistance Obesity is pandemic in the US and many TNBC suffer from this as well Obesity is accompanied by high levels of leptin ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. A Dietary Supplement As Adjunct Therapy In Castration-Resistant Prostate Cancer

    SBC: MetCure Therapeutics LLC            Topic: 102

    DESCRIPTION provided by applicant Castration Resistant Prostate Cancer Castration resistant prostate cancer CRPC directly contributes to patient mortality It is imperative to develop new and effective adjunct therapy to enhance the response of CRPC to hormonal therapy Recently we developed ProFineTM a proprietary formula consisting of bioactive flavonoids enriched in pomegranate fruit and ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government