Award Data

DESCRIPTION (provided by applicant): This Small Business Innovation Research project addresses the development of a low-cost personal exposure monitor with real-time sampling and data logging capabilities for the dry cleaning industry. Phase I research eff orts were focused on the development of chemical micro-sensors for detecting perchloroethylene vapors. Phase II research studies will enable th ...

DESCRIPTION (provided by applicant): Individuals with disabilities who require the use of wheelchairs for all of their independent mobility often experience problems with chronic seat discomfort in their wheelchairs. In spite of this prevalent problem, very little research has been done and few products have been specifically developed to mitigate chronic wheelchair seat discomfort. Chronic wheel ...

DESCRIPTION (provided by applicant): The long-term objective of the proposed work is the development of innovative detection technologies for biochips (a.k.a. DNA microarrays). It is envisioned that the proposed technologies will enable the application of biochips to biodefense, particularly when a rapid and reliable diagnostic screen is required in the field. The Specific Aims of the proposed wo ...

DESCRIPTION (provided by applicant): Type I diabetes mellitus is an autoimmune disease that destroys the insulin-producing cells of the pancreas. This disease affects an estimated one million Americans and usually finds its onset in childhood or in you

DESCRIPTION (provided by applicant): Recent reports indicate that adolescents are not following the Dietary Guidelines and are far from attaining the Healthy People 2010 nutrition goals. Most eat too much fat and sodium and inadequate amounts of fruits, vegetables, and calcium. They are snacking more, on less nutritional foods. In addition, there is an alarming increase in the prevalence of obesi ...

DESCRIPTION (provided by applicant): Increasing physical activity and developing healthy eating habits, particularly eating more fruits and vegetables during childhood, can help reduce chronic disease risk. However, activity levels decline as children gr

DESCRIPTION (provided by applicant): Increasing physical activity and developing healthy eating habits, particularly eating more fruits and vegetables during adolescence, can help reduce chronic disease risk. However as adolescents grow older, activity

N/A

DESCRIPTION (provided by applicant): Bisphosphonates are currently used as bone-specific palliative treatments for the tumor-induced bone diseases observed in breast cancer and multiple myeloma patients. However, bisphosphonate use has no proven impact on primary tumor burden and overall survival and only moderately reduces skeletal complications. Bisphosphonate conjugates were synthesized using ...

DESCRIPTION (provided by applicant): Bisphosphonates (BP) are a class of anti-resorptive drugs that target metabolic bone diseases characterized by accelerated states of skeletal turnover, such as post-menopausal osteoporosis. BPs have a high affinity for hydroxyapatite in bone matrix where it is released and incorporated by the osteoclast during bone resorption. Once intracellular, the BP disrupt ...