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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Non-surgical treatment option for pelvic organ prolapse

    SBC: Reia, LLC            Topic: NICHD

    Project SummaryAbstract Reia is working to address a prevalent gynecological conditionpelvic organ prolapsePOPwhich affects more thanof women over the age ofPOP occurs when the pelvic floor connective tissue and muscles weakenallowing the uterus or vaginal walls to descendIn extreme casesthe uterus descends through the opening of the vagina and hangs outside of the bodyPOP can be treated non surgi ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Targeting leukocyte metabolism to treat human autoimmune disease

    SBC: Immunext, Inc.            Topic: R

    ImmuNext has defined an anti MCTmonoclonal antibodymAbthat will be developed for the treatment of human autoimmune diseaseThe membrane monocarboxylate nutrient transporter SLCAMCTis a multi pass transmembrane protein responsible for the facilitated transport of critical metabolitesincluding products of glycolysislactatepyruvate and ketonesOur strong preliminary data support the tenet that mAbs tha ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Complex 3-Dimensional in vitro Human Skin Tissue Models for Scleroderma

    SBC: CELDARA MEDICAL, LLC            Topic: NIAMS

    PROJECT SUMMARY Sclerodermasystemic sclerosisSScis an autoimmune disease of unknown etiology that is characterized by vascular dysfunctionfibrosisand inflammationOne in three patients dies withinyears of diagnosisgiving SSc the highest case fatality rate of any systemic autoimmune diseaseA lack of biologically relevant SSc disease models has created a critical unmet need for more efficient preclin ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. Optimized Dry Powder Formulation and Delivery for Inhaled Clofazimine

    SBC: CREARE LLC            Topic: NIAID

    Treatment regimens for multi drug resistant tuberculosisMDR TBinvolve a spectrum of second tier drugs delivered over a long periodoften over a yearA drug that has shown promise in short regimenssuch as the Bangladesh regimenis oral ClofazimineCFZbut tolerance to oral CFZ is limitedInhaled delivery could potentially limit adverse effects and maximize delivery to the infected pulmonary tissueFormula ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Discovery of novel helminth immunomodulatory proteins for autoimmune diseases

    SBC: CELDARA MEDICAL, LLC            Topic: NIAID

    This contract aims to identify novel parasite derived protein candidates as biologics to treat Crohn s and other diseases with high healthcare costs and no truly long term effective treatment optionsWe will screen stage specific proteins from Onchocerca volvulus that conceivably enable this parasitic helminth to chronically infect the human host by continuously modulating the innate and adaptive i ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Multi-Spectral Infrared Focal Plane Array For Wildfire And Burning-Biomass Analysis

    SBC: QmagiQ, LLC            Topic: S1

    An important NASA mission is to remotely analyze fires, such as wildfires and burning biomasses, for their chemical content. The chemical species of most interest have infrared spectral signatures at wavelengths ranging from 1.5 microns to 12 microns. A broadband infrared focal plane array (FPA) with that spectral coverage and high quantum efficiency is a key technology to enable this mission. Qma ...

    SBIR Phase I 2018 National Aeronautics and Space Administration
  7. Optically Interrogated Thin Film Strain Gauge for Balloon

    SBC: CREARE LLC            Topic: S3

    To support development of atmospheric balloons and gossamer structures, NASA requires a capability for real-time, dynamic strain measurement in thin polymeric membranes during deployment and flight.  This capability will provide quantitative test data to inform balloon design efforts, as well as enable real-time monitoring of material state during flight.  Existing technologies include w ...

    SBIR Phase I 2018 National Aeronautics and Space Administration
  8. High Efficiency 4 K Cryocooler for Space Missions

    SBC: CREARE LLC            Topic: S1

    Future astrophysics missions require efficient, low-temperature cryocoolers to cool advanced instruments or serve as the upper stage cooler for sub-Kelvin refrigerators. Potential astrophysics missions include Lynx, the Origin Space Telescope, and the Superconducting Gravity Gradiometer. Cooling loads for these missions are up to 300 mW at temperatures of 4 to 10 K, with additional loads at higher ...

    SBIR Phase I 2018 National Aeronautics and Space Administration
  9. ASOMIS

    SBC: APPLIED GEOSOLUTIONS LLC            Topic: S5

    The innovation of the Agricultural SOil Moisture and Irrigation Status (A·SOM·IS) platform is the development of operational and moderate resolution mapping and assessment of soil moisture, irrigation status (irrigated vs not), and crop water stress metrics at field scale for agricultural decision support tools. The platform focuses on utilization of Synthetic Aperture Radar (SAR) an ...

    SBIR Phase I 2018 National Aeronautics and Space Administration
  10. A Compact, Lightweight Electrically Driven Propellant Pump with High Pressure Rise

    SBC: CREARE LLC            Topic: S4

    Reducing the inert mass of propulsion systems in sample return spacecraft will reduce their launch costs and increase opportunity for these missions. Compared to a pressure-fed system, a propellant pump-fed system can significantly reduce overall propulsion system mass, especially for a system with high propellant throughput. To address this need, we propose to develop a compact, lightweight elect ...

    SBIR Phase I 2018 National Aeronautics and Space Administration

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