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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Oral Enzymatic Management of Phenylketonuria

    SBC: Abri Science, LLC            Topic: 300

    PhenylketonuriaPKUis a genetic disorder of metabolism characterized by a pathological elevation of phenylalaninePhein the body stemming from a dysfunctional phenylalanine hydroxylase enzymePAHThe resulting high concentrations of Phexcan result in severe intellectual disabilitybehavioral problemsand neurological deficitse gseizuresStrict control of dietary Phe is the primary treatment for PKU curre ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Novel insulin-sensitizing NASH/diabetes drugs.

    SBC: BIOIO, LLC            Topic: 300

    Obesity is associated with an increased risk of a number of chronic and progressive diseases and obesityrelated metabolic diseases constitute a significant public health burdenThe increased likelihood of developing insulin resistance and diabetes is probably the most commonly recognized risk of being obeseIn additionobesity is also associated with accumulation of lipid in the liver parenchymahepat ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Infection Site Targeted Antitoxin Antibody (ISTAb) against Bacillus anthracis

    SBC: Integrated Biotherapeutics, Inc.            Topic: NIAID

    Project Summary Bacillus anthracisBais a Gram positive spore forming bacterium that is listed as an agent of highest concernCategory Aby NIAID and CDCBa is easy to growand its spores can be formulated into highly stable powder form and disseminated as aerosol or used to contaminate food or waterInletters laced with powdered anthrax spores were mailed to several US politiciansTwenty two peopleinclu ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Multielectrode Arrays for Neurotransmitter Detection with Fast Scan Cyclic Voltammetry

    SBC: Microprobes for Life Science, Inc.            Topic: 101

    Project Summary Abstract The brain is by far the most complex and heterogeneous organ in the human bodyFor yearsthere has been a growing and unmet need to develop multielectrode arrays for neurotransmitter sensing in multiple brain regions simultaneouslyDisparate brain regions such as the nucleus accumbensstriatumprefrontal cortexhippocampusand others have been widely known to have greatly varying ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Novel, Potent and Metabolically Stable Oxytocin Analogues to Treat Obesity

    SBC: Oxt Therapeutics, Inc.            Topic: 300

    The goal of this project is to develop novel oxytocinOXTanalogues with improved safety and efficacy vsnative OXT for the treatment of obesity and related metabolic disordersObesity is an increasing health care burden in the US andeven though it is recognized as a significant risk factor for developing cardiovascular disease and typediabetesthere has been limited progress in developing safe and eff ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A New Small-Molecule Kinase Inhibitor for Airway Disease

    SBC: NuPeak Therapeutics, Inc.            Topic: NHLBI

    Abstract NuPeak Therapeutics Incis a biotechnology companyC corporationdesigned to deliver a first in class smallmolecule kinase inhibitorSMKIfor therapeutic use in humansThe present Project is aimed at an inhibitor for treatment of respiratory airway disease especially due to asthma and COPDwhich remain leading causes of morbidity and mortality in the U Sand worldwide despite current therapeutic ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Detection of HIV proteins in urine to diagnose infection

    SBC: Newmark Diagnostics LLC            Topic: NIMH

    PROJECT SUMMARY ABSTRACT The development of a low costpoint of care diagnostic device or kit in arapid testorself testformat would be highly beneficial to the global effort to diagnosemanage and treat HIVWe are proposing to evaluate the scientific finding that HIV proteins are present in urine associated with extracellular vesiclesalso commonly referred to as exosomesThe development of one or more ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Preventing Vascular Complications in Type 1 Diabetes: Muscle Metabolic Monitoring

    SBC: Infrared Rx, Inc.            Topic: NIDDK

    Preventing Vascular Complications in TypeDiabetesMuscle Metabolic Monitoring Abstract Measurements of muscle metabolism and blood flow using near infrared spectroscopyNIRShave progressively increasedas has the number of companies selling NIRS based devicesThis technology represents the present and future modality for non invasively characterizing normal and abnormal muscle physiology in health as ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. The Daily Progress System- A Recovery Support Tool to Reduce Health Disparities in Outpatient Substance Use Treatment

    SBC: COG ANALYTICS, LLC            Topic: 102

    ABSTRACTSubstance use disordersSUDsincluding opioid use disorderscontinue to be one of the most serious public health issues in the USleading to negative physical and mental health problemsfamily disruptionand premature deathAfrican Americans with drug use histories that are under criminal justice supervision are particularly vulnerable to experiencing the negative consequences associated with SUD ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Mitofusin agonists to prevent Charcot-Marie-Tooth disease 2A

    SBC: Mitochondria in Motion, Inc.            Topic: NINDS

    Mitofusin agonists to prevent Charcot Marie Tooth diseaseA Gerald W Dorn IIMD Mitochondria in MotionIncWashington University in St Louis School of Medicine AbstractCharcot Marie ToothCMTdisease typeA is an incurableprimarily pediatricautosomal dominant neuromuscular degenerative disease caused by mutations in the mitofusinMFNgeneThere are currently no disease altering treatmentsMitochondria in Mot ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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