Award Data

DESCRIPTION (provided by applicant): Osteoporosis is a major and growing health care problem that responds inadequately to standard pharmacologic therapy. Because of its low bone mineral density, osteoporotic bone is mechanically weak and fractures more easily than normal bone. Moreover, fracture repair is compromised in osteoporotic patients. The work described in this Phase I STTR proposal aims ...

DESCRIPTION: (Adapted from Applicant's Abstract) Malaria is a disease which affects more than 300 million people each year and is fatal for 1.5 million. The overall objective of this STTR Phase I project is to produce a cGMP malaria vaccine consisting of the 42 kDa C-terminal polypeptide of P. falciparum merozoite surface protein-1 (MSP1.42) to be formulated with ...

DESCRIPTION (provided by applicant): Prostate cancer is the most prevalent cancer among men; and the second leading cause of cancer death among men in the US. There are currently no approved therapies for hormone-refractory prostate cancer. Epidemiological studies have demonstrated a strong relationship between incidence of and mortality from various cancers including prostate cancer, exposure to ...

DESCRIPTION (provided by applicant): Injury is a well established risk factor in the pathogenesis of osteoarthritis (OA) as supported by several large longitudinal population studies. Patients with meniscal and ACL injuries in particular are at risk for early OA. Chondroprotection of the joint surface is mediated by lubricin which forms an ordered nanofilm and provides anti-adhesion via steric rep ...

Static organization charts and standard processes define roles, methods, and authority in useful ways for common missions. But these same, rigid structures force the organization to behave inefficiently, often ineffectively on problems in new domains, problems requiring new coordination methods and ad hoc teams. What is needed to facilitate rapid formation of effective human networks is a system ...

Decades of exponential advancement in computer capabilities have transformed the world, from toddlers’ playthings to the technologies of war and peace. Some further advances are constrained by the limits of von Neumann machines; in particular, they do not learn well. Aptima proposes to conduct a feasibility study to design “UBER-HEB,” a non-von Neumann hierarchical universal learning system. ...

Argolyn Bioscience Inc. is an early stage biotechnology company that creates novel peptide drugs and diagnostics with greatly improved intrinsic pharmaceutical properties through substitution of non-natural amino acid analogues for arginine (Arg) or lysine (Lys). In proof-of concept studies thus far, application of the Argolyn technology to peptides of therapeutic interest has resulted in dramatic ...

DESCRIPTION (provided by applicant): The brain peptide neurotensin (NT) and its active derivative NT [8-13] function as endogenous neuroleptics. Stable NT derivatives that cross the blood brain barrier therefore have significant potential for development as a new class of non-dopamineric antipsychotics expected not to display the adverse side effects associated with the dopaminergics. The best lit ...

DESCRIPTION (provided by applicant): The overall aim of this STTR proposal is to take an innovative, successful; laboratory based technology and transfer it to the commercial sector. Specifically, we wish to establish the capabilities within the Company to manufacture reliable, robust and inexpensive ultra-micro oxygen sensors suitable for electrochemical applications related to cellular metabolis ...

DESCRIPTION (provided by applicant): The primary goals of stem cell biology are to develop practical cell-based tools: 1) to enhance the repair of damaged organs and tissues; and 2) as vehicles for gene therapy to introduce engineered genes to the body to either correct a genetic defect or to provide therapeutic molecules. The use of embryonic stem cells is both controversial and fraught wit ...