Award Data

DESCRIPTION provided by applicant Ebola and Marburg viruses belong to the family Filoviridae and can cause fatal hemorrhagic fevers characterized by widespread tissue destruction with an incubation period of days Because of the safety concerns these viruses are designated as the biosafety level agents Currently there is no effective vaccine or therapeutic treatment against filoviral i ...

DESCRIPTION provided by applicant Lassa fever virus LASV and Machupo virus MACV are hemorrhagic fever arenaviruses which are classified as Category A Agents Currently there are no licensed LASV or MACV vaccines and LASV MACV therapy is limited to use of the nucleoside analog ribavirin which is only partially effective and associated with significant side effects The impact of arenavirus ...

DESCRIPTION provided by applicant One of the challenges of research in infectious diseases is to find ways to use the increasing knowledge of the mechanisms underlying disease transformation and progression to develop novel therapeutic strategies for diseases such as increasing menace of bacterial infections Targeting specific RNA such as rRNA which are involved in proliferation and survival ...

We propose to utilize a laser 3D printing manufacturing technique to realize an ultra high efficiency micro-channel laser head cooling system with high thermal load capacity in a small volume package. The new approach incorporates key technical innovations that drastically increase the forced water flow interaction surface area and the metal thermal conductivity. The approach enables conformal geo ...

The littoral environment is especially demanding on tactical sonar systems, in large part because the spatial and temporal variability imposes sonar system operating conditions of a nature and with a scale heretofore not encountered in the open oceans. Recent Office of Naval Research (ONR) sponsored basic research as well as fleet exercises have shown that littoral environments tactically importan ...

As the number of emerging warfare capabilities increases, adaptive training is required in order to keep pace with the corresponding increase in the scale and complexity of training regimes. To enable truly adaptive training, training systems need to both (1) automatically generate training scenarios and (2) automatically assess trainee performance. Lastly, (3) diagnostic visualization technologie ...

Physical Sciences Inc. (PSI) will develop novel feedstocks for 3D printing of lithium-ion batteries using existing additive manufacturing technologies. Lithium-ion batteries simultaneously offering high energy and power density energy will be demonstrated using the novel feedstock materials. PSI’s proprietary HA coating technology will be utilized in the feedstock formulations to maximize active ...

Demand for portable power continues to expand, and new portable devices require increased variability in form factor. Furthermore, expired batteries may not be easily replaceable due to the lack of standard geometries. New manufacturing technologies are necessary to respond to each of the challenges. Additive manufacturing (AM) is a promising approach that is well known for its ability to quickly ...

Providing effective cyber defense for the DoD is compounded by the fact there is not a single physical or logical entity that defines cyberspace. In reality, DoD networks are often composed of three disparate but interacting layers: a physical layer that defines the structure of the network (e.g., computers and routers), a logical layer that represents the static or dynamic state of data within th ...

UUVs have become increasingly important tools in the collection of environmental data. Their unique ability to operate independent of surface vessel conditions allows oceanographic seawater measurements when traditional means is not possible. Historically sensor packages for UUVs have been based on adaptions of ship deployed equipment. Recent development in sensors, such as the Hybrid Flow Through ...