Award Data

DESCRIPTION (provided by applicant): Project Summary/Abstract Atrial fibrillation is the most common disorder of the heart rhythm that requires treatment, with a prevalence estimated at over 5 million in the US alone in the year 2000. If untreated, it is a ssociated with increased risk of death and disability, primarily due to stroke. There is increasing evidence that a significant percentage of a ...

Abstract AsystBio LLC proposes to market a molecular tool kit called AML MutationCounter to count somatic mutations in genes that contribute to the development of acute myeloid leukemia AML We have developed a set of reagents and computer programs for application of next generation sequencing to count AML gene mutations The tool kit is versatile and can be used with either of the two major DNA ...

Project SummaryA significant cause of mobility impairment in the elderly is peripheral arterial diseasePADPAD results in significant functional declinereduced walking speed and distanceand lower physical activity levelsresulting in a loss of independence and impaired quality of lifeThe most effective therapy for PAD is rigorous exercisee gwalkingHowevermost PAD patients will not participate in sup ...

DESCRIPTION (provided by applicant): Molecular interactions are central to the understanding of basic biology and cellular function, are paramount to all molecular assays (research and in vitro diagnostics), are essential in biomarker discovery and critical toward evaluating therapeutics. However, the tools available to quantify these interactions have limitations, in so far as they either rely up ...

DESCRIPTION (provided by applicant): Molecular interactions form the foundation of biology and chemistry. They are central to life itself and determine catalytic activity, cellular function, and therapeutic efficacy. The vast majority of diagnostic procedures depend on some type of specific molecular interaction. Therefore, the ability to perform pure liquid-phase molecular binding analysis at hi ...

DESCRIPTION (provided by applicant): A major contamination issue at over 8,000 sites in the United States are PAHs. This contamination results from almost all combustion processes, creosote treatment of wood, former town gas sites, and many others. Many of these chemicals are both toxic and carcinogenic. It has been observed that these highly hydrophobic chemicals bind tightly to soil by a numb ...

DESCRIPTION (provided by applicant): The standard interpretation of electocardiographic data does not allow differentiation of certain types of rhythm disorders, necessitating invasive testing. We believe that there is additional information contained in the ECG, in the form of small but systematic phase and amplitude changes that may provide important localization information. We will use inve ...

Pulmonary hypertensionPHis a disease affecting approximatelyof the general population that is characterized by abnormally elevated mean pulmonary artery pressuremPAPand pulmonary vascular resistancePVRIf left untreatedPH can ultimately lead to right heart failure and deathCurrent diagnostic approaches utilize invasive right heart catheterizationRHCto measure mPAP and PVREarly detection of PH leads ...

DESCRIPTION (provided by applicant): The physical fitness and strength requirements for lower limb amputee gait are so high that thirty-seven percent of amputees are unable to walk with a prosthesis and another twenty-three percent are able to ambulate indoors only. Recent advances in prosthetic feet and knees have been unable to reduce these requirements, and external assistive devices like powe ...

PROJECT SUMMARY Atypical teratoid/rhabdoid tumors (AT/RT) are rare embryonal central nervous system malignancies that occur in early childhood and are lethal. Current treatment strategies for children diagnosed with AT/RT are limited to surgery, radiation, and chemotherapy, but to date, none of these have successfully improved survival beyond 18 months, and most are associated with significant tox ...