Award Data

DESCRIPTION (provided by applicant): The objective of the proposed project is to advance the development of novel peptides targeting MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) protein as platform drug molecules for the treatment of Acute Lung Injury (ALI) and its more severe form, Acute Respiratory Distress Syndrome (ARDS), thereby providing the first pharmacologic therapeutic for this ...

PROJECT SUMMARY ABSTRACT Antiviral vaccines remain the largest segment of the rapidly growing global vaccine market Despite near complete eradication of poliovirus through vaccination efforts continued need for inactivated polio vaccine IPV is projected to reach million doses per year worldwide Among major obstacles to widespread use of the current IPV formulation are its high cost and in ...

Project Summary Abstract The goal of this proposal is to develop a novel high throughput platform for understanding gene regulatory elements in order to identify new drug targets for common diseases The human genome encodes approximately genes Understanding how those genes are regulated and how this correlates to complex cell phenotypes has long been a major focus of our team Follow up p ...

DESCRIPTION provided by applicant Osteoarthritis OA is the most common form of arthritis and the leading cause of disability in adults and the aging population There is no cure for OA Current treatments mainly focusing on pain management and improving or sustaining function and have no clearly demonstrated beneficial effect on chondroprotection or OA disease modification Long term use of ...

DESCRIPTION (provided by applicant): Bone marrow failure is also a frequent iatrogenic side-effect of radiotherapy and chemotherapy. Bone marrow failure can be caused by whole body exposure to even low doses of radiation. Strong radiation or chemotherapy can destroy metastatic cancers that have spread around the body but these aggressive treatments can end up bone marrow failure resulting in killi ...

DESCRIPTION provided by applicant A Quad Fast MAS probe for Dramatically Improved Biomolecular Structure Determinations Abstract The last years have seen steady progress in applying magic angle spinning MAS NMR to an increasingly wide range of applications in structural biology However the methods are all far from routine and often require mg of a concentrated sample that is extrem ...

DESCRIPTION provided by applicant A recent outbreak of carbapenem resistant Enterobacteriaceae CRE associated with contaminated duodenoscopes at the Ronald Reagan UCLA Medical Center highlights the importance of early detection of these clinically significant pathogens Coincidentally the Obama Administration released The National Action Plan to Combat Antibiotic Resistant Bacteria for which ...

DESCRIPTION provided by applicant Lyme disease caused by infection with Borrelia burgdorferi is the most common vector borne infectious disease in North America and Europe Early disease can be effectively cured with antibiotics however untreated late disseminated infection can result in permanent damage to the nervous and musculoskeletal systems Therefore early diagnosis is critical for ...

DESCRIPTION provided by applicant The goal of this project is to develop a commercial software package for rapid Monte Carlo based dose computation in imaging and radiation therapy The product takes advantage of a desktop parallel computer equipped with emerging hardware originally developed gaming and high performance computing The project is motivated by the fact that the market is ripe for ...

Abstract The goal of this fast-track SBIR proposal is to file an investigational new drug (IND) application for testing a novel anticancer drug (FL118) that is designed to overcome inherent and acquired treatment resistance. Many types of cancers are not detected until they are very advanced and have already become resistant to FDA approved treatments. In addition, many non-advanced cancers respon ...