Award Data

DESCRIPTION provided by applicant Photodynamic therapy PDT provides for standalone or intraoperative cancer treatment PDT provides a means to treat superficial and or residual disease while minimizing damage to underlying tissues and does not exhibit cumulative cell toxicities distinguishing it from radiation therapy As compared to radiotherapy treatment planning in PDT is often approa ...

DESCRIPTION provided by applicant The Fontan procedure or total cavopulmonary connection TCPC is a standard palliative surgery for patients with complex single ventricle congenital heart anomalies TCPC connects the inferior and superior vena cava IVC and SVC directly to the right pulmonary artery bypassing the heart The single ventricle is then reserved for pumping oxygenated blood to th ...

Project Summary This direct Phase II SBIR proposal focuses on the development of recombinant human MGrhMGa novel tissue repair proteinas a therapeutic candidate targeting injury of renal epithelium to protect against acute kidney injuryAKIAKI is commonly encountered in the hospital and outpatient settings and is associated with a high rate of mortalityCurrentlythere is no effective means for preve ...

DESCRIPTION provided by applicant Worldwide a person dies from cancer every seconds Positron emission tomography PET is an effective tool that is critical in diagnosing cancer and monitoring treatment efficacy PET imaging relies on use of short lived radioisotopes Commercial distribution of the most commonly used radio tracer F FDG has resulted in patient population coverage in ...

Aflatoxins are a paradigm among fungal produced mycotoxins that are present in food supplies and are strongly associated with increased risk forthe development of hepatocellular carcinoma. Currently, there are no known countermeasures that can selectively mitigate aflatoxin toxicity andthe available options are only symptomatic treatments. To meet this challenge, we propose to harness the microbio ...

DESCRIPTION provided by applicant The overall goal of the proposed project is to leverage a widely disseminated elementary alcohol and other drug use prevention curriculum to create a mobile version that enhances engagement and promotes transfer of learning to out of class decisions The project represents a collaboration among three businesses dedicated to innovative use of technology for alco ...

DESCRIPTION provided by applicant DiscoveryBioMed Inc DBM Inc or DBM specializes in normal and diseased human cell platform engineering DBM has assembled a consortium of experts whereby collectively we seek Fast Track SBIR funding to establish and offer a Product Line Menu of normal and ADPKD human cell platforms for the academic and industry marketplaces Existing and interested DBM ...

Glycosaminoglycan Interacting Small Molecule GISMO As Parkinsonandapos s Therapeutics ABSTRACT Current approved drugs for Parkinsonandapos s Disease PD treat the symptoms of the disease but do not stop disease progression This project is focused on developing a new disease modifying PD therapeutic with a novel mode of action that is expected to block disease progression Recent data indicate ...

DESCRIPTION provided by applicant Urinary incontinence UI and overactive bladder OAB are highly prevalent in women and their prevalence is increased with the age In a representative United States survey UI was reported to affect from to of women The OAB prevalence estimates vary considerably among studies ranging from to These conditions are socially embarrassing causin ...

Ovarian cancer OC disproportionately affects the women of African American AA background at all stages of the disease from presentation through treatment Most upsetting fact is that AA patients have greater mortality and their survival rates are continuously decreasing as compared to Caucasian American CA Success in understanding and characterizing the involved mechanisms in existing rac ...