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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Diagnosing aggressive prostate cancer by spectroscopic photoacoustic tomography

    SBC: Vibronix, Inc.            Topic: 102

    DESCRIPTION provided by applicant Prostate cancer PCa is the No killer among male cancer patients The ultimate test is based on transrectal ultrasound guided needle biopsy and histological examination of fixed prostate tissues This conventional diagnostic procedure is invasive missing cases of cancer due to small sampling volume Moreover it leads to an overtreatment of patients du ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Maximal MYC control using dual PI-3K/BRD4 (kinase/epigenetic) inhibitors

    SBC: SignalRx Pharmaceuticals Inc.            Topic: 102

    DESCRIPTION provided by applicant There is an unmet need to inhibit the key cancer promoting transcription factor MYC MYC both cMYC and MYCN acts downstream of many cell receptor complexes and signal transduction pathways to activate genes that drive cancer cell growth and proliferation To date small molecule inhibitors of MYC have been elusive An innovative approach would be to indirectl ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. A new treatment for NSAID-associated gastrointestinal damage

    SBC: Anteana Therapeutics Inc            Topic: NIDDK

    DESCRIPTION provided by applicant Non steroidal anti inflammatory drugs NSAIDs are among the most widely consumed pharmaceuticals but their prolonged use causes gastric injury and damage to the small intestine Previous work has shown that anandamide an endogenous endocannabinoid substance produced in the gastrointestinal GI mucosa plays an important role in epithelial homeostasis and re ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. A new generation of targeted therapeutics for the treatment of cancer

    SBC: NERX BIOSCIENCES, INC.            Topic: NCI

    DESCRIPTION provided by applicant Development of novel lung cancer therapeutics targeting the DNA damage response Abstract Lung tissue is constantly exposed to a wide variety of inhaled chemical agents While the majority of these maybe innocuous those that damage DNA have severe consequences Thus the DNA damage response DDR and DNA repair in these tissues is extremely important The vast ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Therapeutic Antibodies for Biofilm Infections

    SBC: TRELLIS BIOSCIENCE, INC.            Topic: NIAID

    DESCRIPTION provided by applicant About of serious bacterial infections are biofilm mediated Not only do biofilms provide an anchor and physical protection for bacterial cells but the physiology and genetic programming of bacteria also shifts between the planktonic free floating and sessile stationary states Most notably antibiotic sensitivity differs betwen the two states with ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Pre-clinical Development of a Vaccine for the Treatment of Heroin Addiction

    SBC: MOLECULAR EXPRESS, INC            Topic: R42

    DESCRIPTION provided by applicant Heroin and related opioids are highly addictive drugs known for their analgesic properties Since the number of heroin users in the United States has skyrocketed reaching epidemic levels Abuse of prescription opioid pain relievers oxycodone Oxycotin and hydrocodone Vicodin which are known gateway drugs to heroin has also increased dramatically Beca ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. A Tool for Research on Emotion in Naturally Occurring Speech

    SBC: Converspeech LLC            Topic: NLM

    DESCRIPTION provided by applicant A Tool for Research on Emotion in Naturally Occurring Speech It is now widely accepted that defects or limitations in emotion processing underlie many disorders such as anxiety depression bipolar and eating disorders If bio behavioral markers of emotions could be found researchers would have the basis for investigating emotions in both normal mental functi ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Macromolecule Crystallization Screening Results Analysis

    SBC: iXpressGenes, Inc.            Topic: 100

    DESCRIPTION provided by applicant Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite techno ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. BlueBox- a complete code blue data recorder

    SBC: NeoVative, Inc.            Topic: 400

    DESCRIPTION provided by applicant andquot Code blue andquot the term used in hospitals to call for an immediate cardiopulmonary resuscitation CPR signals dire emergencies where medical errors can occur and lives can be lost Reviewing CPR performance of the code blue team is a cornerstone for improving outcomes Thorough and accurate recording of code blue events enable detailed reviews to ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Wearable Ultralow Power Personal Exposure Monitor for Atmospheric Pollutants

    SBC: KWJ ENGINEERING INC            Topic: NIEHS

    DESCRIPTION provided by applicant The goal of this STTR Phase I collaboration between KWJ Engineering KWJ and North Carolina State University NCSU will be development of a unique autonomously powered wearable environmental gas sensor for personal exposure monitoring PEM The approach will be to integrate KWJ ultralow power high performance printed amperometric gas sensor for key atmosp ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
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