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SBC: Sersense Inc Topic: NICHD
PreeclampsiaPEis a pregnancy specific disorder characterized by hypertension and commonly by the appearance of urinary proteinThis disorder occurs inof pregnancies worldwide and is the second leading cause of maternal fetal morbidity and mortality worldwideIn low resource settingsPE accounts for up toof maternal deathsThe etiology of this disease is poorly understoodThis confounds therapeutic inte ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: SERPLUS TECHNOLOGY LLC Topic: 200
The number of people with diabetes worldwide is predicted to increase frommillion intomillion inThe health care costs of treating the disease account forof the global health expenditure and continue to be a huge economic burdenIDF World AtlasTypediabetes mellitusT DMconstitutesof the disease burdenIt is an autoimmune diseasethought to be triggered by genetic or environmental factors in early child ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: BIOSENSICS LLC Topic: NIA
Project Summary The overall goal of the proposed work is to develop a platform capable of delivering and monitoring adherenceproficiencyand safety of a home based simplified Tai Chi intervention for older adultsDuring Phase I of this Fast Track STTR project we will further develop a novel approach to assessing Tai Chi performance adherenceproficiencyand safety based on wearable sensor dataMetrics ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Insightful Surgical Vision Technology (ISVision) for intelligent real-time display of anatomic, physiologic, and pathologic information in surgerySBC: Activ Surgical Inc Topic: NIBIB
Abstract Intelligent intraoperative display of anatomic and physiologic information coupled to real time situational awareness to critical tissues will benefit all surgeryThe current surgical vision is limited to naked human eyes in open surgery or more recently using laparoscopic digital imaging for minimally invasive surgery and robot assisted surgeryIn laparoscopic visionalthough the visualizat ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Leaflabs, LLC Topic: 101
PROJECTSUMMARY Scaling extracellular electrophysiology to higher channel counts is hindered by the burden of data handling storageand especially preprocessinge gspike sortingThe burden of spike sorting can in principle be reduced through a combination of high density multielectrode arrayprobetechnology and algorithm optimization to yield a spike sorting method that is both highly accurate and full ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
The Microscopic Imaging of Epigenetic Landscape- NeuroDevelopment (MIEL-ND) assay: a high throughput platform to screen compounds for neurodevelopmental effectsSBC: VALA SCIENCES, INC. Topic: 101
Neurodevelopmental diseasesNDDsAutism Spectrum DisorderASDIntellectual DisabilitiesBipolar disordersand Schizophreniaetcare prevalent and due to errors in neurodifferentiation and neurocircuitryWhile NDDsin many casesare due to inherited mutationsevidence is mounting that prenatal exposure to environmental toxicants also cause NDDs via disruption of epigeneticse gmodifications of histoneshistone t ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Enepret Incorporated Topic: NIAID
ABSTRACT Vaccine adjuvants help stimulate the body to generate an immune response when co injected with an antigenthe compound for which immunity is desiredAlthough the human body is capable of producing antibodies to most injected antigensadjuvants can help boost the body s ability to mount a successful and acquired immune response to the presented targetAdjuvants have been shown to enhance immun ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Cavatar LLC Topic: NCI
PROJECT SUMMARY This proposal aims to develop a novel caveolae targeting antibody for rapid clinical translationIts long term objective is to develop the caveolae pumping systeman active transendothelial transport pathwayto provide an effective solution to the delivery and toxicity problem of systemically administered chemotoxinsWork will be based on the current proprietary mouse monoclonal antibo ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Xona Microfluidics, Inc. Topic: 101
New pharmacological treatments for epilepsy will be discovered through the development of new screening platforms that are rapidreliableand can identify novel disease modifying therapiesor anti epileptogenic treatmentsXona MicrofluidicLLCXonais in a unique position to provide such screening tools and services for epilepsy researchXona focuses on the development of microfluidic platforms for neuron ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: DISCOVERYBIOMED, INC. Topic: NIDCD
Principal Investigators for Small BusinessDiscoveryBioMedIncDBMand Monell Chemical Senses Center Project Summary Abstract Bitter taste in foods and medicines presents a barrier to overcoming global public health challengesfood insecuritypoor nutritional healthand poor compliance with medication useparticularly among children and the elderlySugar and saltthe mainstays to address these challengesfur ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health