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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Chromatography-Free Antibody Purification by Affinity-Phase Separation

    SBC: Isolere Bio, Inc            Topic: 400

    Abstract The objective of this NIH Phase II SBIR proposal is to demonstrate the commercial feasibility of IsoTaga novel cost effective method to purify monoclonal antibodiesmAbsthat eliminates the need for Protein APrAchromatographyThis objective will be achieved by using a recombinant fusion comprised of a stimulus responsive elastin like polypeptideELPthat can undergo a reversible soluble to ins ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. BurntOut: Role-Play Simulation for Building Medical Student Resiliency

    SBC: Clinical Tools, Inc            Topic: 400

    PROJECT DESCRIPTIONBurntOutRole Play Simulation for Building Medical Student Resiliency Medical student and physician burnout rates are highRates correlate with alcohol and other substance use problemsand negatively impact patient careThis project will create aD simulation BurntOutRolePlay Simulation for medical students to practice and respond to stressful situationsenhance copingand develop ways ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Development of an oral therapeutic to mimic the anti-diabetic effects of gastric bypass surgery

    SBC: BIOKIER, INC.            Topic: 200

    SUMMARY Glucose homeostasis and food intake are both regulated by gut hormones secreted from enteroendocrine Lcells in the lower gut following stimulation by nutrientsThis process is impaired in diabetes but is restored with delivery of dietary nutrients such as amino acids and fatty acids to the lower gutsuch as after gastric bypass surgery and during fermentation of carbohydrates in the colonbot ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Multi-Omic Single-Cell System for Improved Combination Cancer Immunotherapy Monitoring and Implementation

    SBC: IsoPlexis            Topic: 102

    IsoPlexis proposes to deliver a novel multi omic method for targeted profiling of both the TCR sequence and proteome from an array ofsingle cellsSpecificallywe will deliver a single cellTCR sequencing and protein capture assay for identifying responsive antigen specific TCRsand concurrently evaluate these T cells for functional response to that antigenThe challenge remains to link the activation o ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Co-culture cassette for anaerobes and primary human intestinal epithelium

    SBC: Altis Biosystems, Inc.            Topic: 300

    Project SummaryThe human colon is a remarkable organplaying critical roles in drug uptake and metabolism as well as harboring thetrillion microbial cells of the microbiomewhich itself has multiple impacts on human healthFor these reasonsthere is a widespread need in academia and the biotechnology marketplace for in vitro studies of human colon physiology and the interaction between colon tissue an ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Cross-Protective Multivalent Vaccine for Tick-Borne Flaviviruses

    SBC: Hawaii Biotech, Inc.            Topic: NIAID

    Project Summary AbstractThe NIH NIAIDStrategic Plan is specifically directed at promoting research that can provide solutions to mitigate the threat posed by emerging and re emerging diseasesThe tick borne flavivirusTBFVgroup includes a number of important human pathogens that result in serious neurological or hemorrhagic diseases that are either Category B or C priority pathogensThe TBFVs are con ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Increased sensitivity of minimal residual disease monitoring using peripheral blood in pediatric patients with acute lymphoblastic leukemia

    SBC: BIOFLUIDICA, INC.            Topic: 102

    Abstract Acute lymphoblastic leukemiaALLis the most common malignant disease in childhood and accounts for approximatelyof all cancers diagnosed before the age ofyearsThe primary cause of death for ALL patients is disease relapseThereforemonitoring for minimal residual diseaseMRDis considered the most powerful predictor of outcome in acute leukemiasincluding B type acute lymphoblastic leukemiaB AL ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Localized Delivery of Sirolimus to Hemodialysis Vascular Access Grafts

    SBC: Cylerus, Inc.            Topic: NIA

    Abstract CylerusIncis developing an implantablesirolimus eluting cuff and reservoir systemcombined with a clinically approved drug pumpto solve the difficult problem of prosthetic vascular graft failureVascular grafts constructed using either synthetic polymers or native veins are widely used in vascular surgeryThe most common indications for these grafts areHemodialysis accessin which blood acces ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School

    SBC: Oregon Research Behavioral Intervention Strategies, INC            Topic: 400

    Abstract Deviant peer affiliation is one of the most important predictors of alcohol use in adolescenceThese affiliations often arise when socially marginalized youth self aggregate and reinforce alcohol use and other deviant activityi edeviant peer clusteringEven though the field has developed efficacious school based prevention programsprogram effects are generally smalland these programs can be ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Selection and preclinical development of a bacteria-targeting, non-antibiotic lead candidate to improve cancer chemotherapy outcomes

    SBC: SYMBERIX, INC.            Topic: 102

    The long term objective of this project is a therapeutic adjunct to prevent chemotherapy induced diarrheaCIDbased on a completely new mechanism of action targeting enteric bacteriaThis Fast Track SBIR proposal outlines the strategy for selecting a lead development candidate to be evaluated in investigational new drugINDenabling studies to support a first in human trialThe focus of this project is ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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