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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of a novel clinical assay for measuring everolimus levels

    SBC: AFFINERGY, LLC            Topic: NIAID

    SUMMARY/ABSTRACT In 2017 nearly 35,000 solid organ transplants were performed in the United States, an increase of 27% over the past ten years. Organ transplantation requires lifelong immunosuppression to prevent rejection of the transplant. Many new classes of drugs have been developed to combat the side effects and interactions common to immunosuppressants, with several agents (sirolimus, everol ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Chromatography-Free Antibody Purification by Affinity-Phase Separation

    SBC: ISOLERE BIO INC            Topic: 400

    Abstract The objective of this NIH Phase II SBIR proposal is to demonstrate the commercial feasibility of IsoTag™, a novel cost-effective method to purify monoclonal antibodies (mAbs) that eliminates the need for Protein A (PrA) chromatography. This objective will be achieved by using a recombinant fusion comprised of a stimulus responsive elastin-like polypeptide (ELP) that can undergo a revers ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. BurntOut: Role-Play Simulation for Building Medical Student Resiliency

    SBC: Clinical Tools, Inc            Topic: 400

    PROJECT DESCRIPTIONBurntOut: Role-Play Simulation for Building Medical Student Resiliency Medical student and physician burnout rates are high. Rates correlate with alcohol and other substance use problems, and negatively impact patient care. This project will create a 3D simulation BurntOut: Role- Play Simulation for medical students to practice and respond to stressful situations, enhance coping ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development of an oral therapeutic to mimic the anti-diabetic effects of gastric bypass surgery

    SBC: BIOKIER, INC.            Topic: 200

    SUMMARY Glucose homeostasis and food intake are both regulated by gut hormones secreted from enteroendocrine L- cells in the lower gut following stimulation by nutrients. This process is impaired in diabetes but is restored with delivery of dietary nutrients such as amino acids and fatty acids to the lower gut, such as after gastric bypass surgery and during fermentation of carbohydrates in the co ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Multi-Omic Single-Cell System for Improved Combination Cancer Immunotherapy Monitoring and Implementation

    SBC: ISOPLEXIS CORPORATION            Topic: 102

    IsoPlexis proposes to deliver a novel multi-omic method for targeted profiling of both the TCR sequence and proteome from an array of 1000+ single cells. Specifically, we will deliver a single-cell, TCR sequencing and protein capture assay for identifying responsive antigen specific TCRs, and concurrently evaluate these T-cells for functional response to that antigen. The challenge remains to link ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Co-culture cassette for anaerobes and primary human intestinal epithelium

    SBC: Altis Biosystems, Inc.            Topic: 300

    Project SummaryThe human colon is a remarkable organ, playing critical roles in drug uptake and metabolism as well as harboring the 100 trillion microbial cells of the microbiome, which itself has multiple impacts on human health. For these reasons, there is a widespread need in academia and the biotechnology marketplace for in vitro studies of human colon physiology and the interaction between co ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Cross-Protective Multivalent Vaccine for Tick-Borne Flaviviruses

    SBC: HAWAII BIOTECH, INC.            Topic: NIAID

    Project Summary/AbstractThe NIH/NIAID 2017 Strategic Plan is specifically directed at promoting research that can provide solutions to mitigate the threat posed by emerging and re-emerging diseases. The tick-borne flavivirus (TBFV) group includes a number of important human pathogens that result in serious neurological or hemorrhagic diseases that are either Category B or C priority pathogens. The ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Increased sensitivity of minimal residual disease monitoring using peripheral blood in pediatric patients with acute lymphoblastic leukemia

    SBC: BIOFLUIDICA, INC.            Topic: 102

    Abstract Acute lymphoblastic leukemia (ALL) is the most common malignant disease in childhood and accounts for approximately 30% of all cancers diagnosed before the age of 18 years (1). The primary cause of death for ALL patients is disease relapse. Therefore, monitoring for minimal residual disease (MRD) is considered the most powerful predictor of outcome in acute leukemias, including B-type acu ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Localized Delivery of Sirolimus to Hemodialysis Vascular Access Grafts

    SBC: Cylerus, Inc.            Topic: NIA

    Abstract CylerusIncis developing an implantablesirolimus eluting cuff and reservoir systemcombined with a clinically approved drug pumpto solve the difficult problem of prosthetic vascular graft failureVascular grafts constructed using either synthetic polymers or native veins are widely used in vascular surgeryThe most common indications for these grafts areHemodialysis accessin which blood acces ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School

    SBC: OREGON RESEARCH BEHAVIORAL INTERVENTION STRATEGIES, INC.            Topic: 400

    Abstract Deviant peer affiliation is one of the most important predictors of alcohol use in adolescence. These affiliations often arise when socially marginalized youth self-aggregate and reinforce alcohol use and other deviant activity (i.e., “deviant peer clustering”). Even though the field has developed efficacious school-based prevention programs, program effects are generally small, and t ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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