Award Data

DESCRIPTION (provided by applicant): The manufacturing of recombinant protein-based biopharmaceuticals is a complex, labor and capital intensive endeavor. It currently is accepted that the use of mammalian cells is a requirement for the production of mosthuman proteins, which typically contain extensive post-translational modifications that are not performed by prokaryotes and single-celled eukary ...

DESCRIPTION (provided by applicant): The overall goal of this proposal is to conduct late-stage preclinical studies to support a pilot clinical trial of hematopoietic stem cell transplantaton gene therapy for hemophilia A. In a series of recent studies, wehave shown that the transplantation of genetically-engineered hematopoietic stem cells can restore factor VIII (fVIII) activity to curative leve ...

DESCRIPTION (provided by applicant): The Climate Risk Analysis Division of Lumenetec, LLC, proposes to develop the Climate Change and Health Gateway (CCHG), an innovative and ground-breaking software tool that will radically enhance biomedical, health andclimate-change informatics. CCHG will empower decision-makers in both the public and private sectors by providing critical, quantitative informat ...

DESCRIPTION (provided by applicant): Schizophrenia is a chronic neurological disorder that affects approximately 1% of the world population and causes gt 60 billion dollars of direct and indirect societal costs in the US alone (Wu et al., 2005). Current therapies to treat this disorder have been effective in ameliorating positive symptoms (hallucinations, delusions, irrational fear), but are le ...

DESCRIPTION (provided by applicant): Anxiety Disorders are some of the most commonly occurring psychological disorders among child and adolescent populations. Cognitive-Behavioral Therapy (CBT) has been proven to be an Evidence-Based Treatment (EBT) to treat anxiety, but there continues to be a lack of available CBT resources for families with anxious youth. Technology-based interventions, includi ...

DESCRIPTION (provided by applicant): The aim of this application is to develop, prototype, validate, manufacture and commercialize a new, generalized microbiosensor designed for non-human use and based on functionalized nanoparticles. The microbiosensors produced will enable in vivo monitoring of a wide range of non-electroactive, neurologically relevant analytes, including, but not limited to, gl ...

DESCRIPTION (provided by applicant): Currently, up to one billion people worldwide suffer from disabling neurodegenerative disorders, including traumatic injuries, stroke and diseases of the CNS such as Alzheimer's and Parkinson's disease (PD). As the number of afflicted individuals substantially grows, it is imperative that more sophisticated, biologically relevant cellular model system ...

DESCRIPTION (provided by applicant): The long-term goal of this project is to create a fun, engaging, and informative videogame called Nurbits that will spark the interest of middle and high school students in neuroscience. Nurbits will be a puzzle/rhythm game based on the principles and processes that underlie synaptic neurotransmission. This game will incorporate our core technologies and an ...

DESCRIPTION (provided by applicant): Tobacco use is the leading cause of cancer death. While daily tobacco consumption in the United States has declined to 18.1%,1, 2 nondaily smoking (smoking on some days but not every day) is increasing,3 particularly among young adults.2 Yet, nondaily smokers are typically excluded from cessation trials.4 Because smokers who quit by 30 have cancer death risk si ...

DESCRIPTION (provided by applicant): This Fast-Track SBIR application submitted by SimpleC of Atlanta, Georgia, requests funds to test our current behavior management technology for persons with dementia (PWD), the SimpleC Companion, and to develop and test a new mobile tablet, the SimpleC Wellness Coach, in the in-home, aging in place market where the overwhelming majority of PWD receive their ca ...