Award Data

Project Summary/AbstractGiven the broad negative effects of low health literacy, national calls from multiple agencies (e.g., Centers for Disease Control and Prevention, American Academy of Pediatrics, World Health Organization, American School Health Association, Society for Public Health Education) have been made to improve health literacy across all levels of the US population. English Language ...

ABSTRACT Manual analysis of biomedical images by researchers and pathologists is time consuming, requires intensive training, and is prone to introduce bias and error. Optical analysis of targets within tissue samples, cultures, or specimens is fundamental to detecting biological properties. Unintentional bias and attentional limitations during analysis of biomarkers can underlie poor reproducibil ...

Project Summary/AbstractIndividuals who have disabilities and health impairments frequently have typically developing (TD) siblings who share high levels of involvement throughout their lifespan. Increasingly, siblings are being recognized by parents, government, and disability service providers as the next generation of caregivers for people with disabilities, yet the risks and stressors they exp ...

ABSTRACTDespite efforts to prevent suicide, US rates are climbing, and suicide is the second leading cause of death amongst youth. Although promising approaches are available for preventative interventions with youth at-risk for suicide, they demonstrate modest benefit, and recent reviews have concluded that new developments are required that facilitate not only greater effectiveness, but also enh ...

Abstract The overarching goal of this project is to create software that improves the use of intracranial EEG to qualify patients with medication-resistant epilepsy for neurosurgery. One million people in the US suffer from continual seizures that are not controlled by medication. The current estimate is that half of these could be treated effectively by surgical resection of the epileptic cortica ...

Parental divorce and separation constitute an adverse childhood experience and a risk factor for a number of childhood behavioral, psychological, and academic problems. The act of parental divorce or separation does not in itself cause adverse outcomes in children. Rather, co-occurring negative family processes, particularly high inter-parental conflict (HIC), explain most of the variance. Althoug ...

Project Summary/Abstract Treatment of patients with myeloproliferative neoplasms (MPNs) is limited to palliative and cytoreductive agents that mitigate proliferative blood counts and their effects. Small molecule selective tyrosine kinase (JAK1/JAK2) inhibitors were also shown to provide modest patient benefit, including reduced symptomatology and improved quality of life. Despite the available th ...

Treatment of non-small cell lung cancer (NSCLC) typically, which requires a combination of many highly toxicdrugs and radiation therapy, is not curative. Immune checkpoint inhibitors (ICIs) targeting PD-L1/PD-1 are causing a paradigm shift in NSCLC treatment, yet the 5-year survival rate remains below 20%.This Fast-Track SBIR application aims to develop a novel nano-immunotherapy (termed ARAC - An ...

7. Project Summary/Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in North America (1). Hepatic steatosis (HS) is the hallmark of NAFLD (2). NAFLD may transition in sub-groups to chronic inflammation (non- alcoholic steatohepatitis, NASH), and ultimately to cirrhosis. HS is prevalent in all stages of NAFLD. 3-10% of all children in the US and 40-70% of obese ch ...

The purpose of this application is to perform the necessary clinical studies to seek regulatory approval for an artificial intelligence (AI) software as medical device (SaMD) for retinopathy of prematurity (ROP) diagnosis. ROP is a leading cause of childhood blindness worldwide, with approximately 50,000 babies going blind annually, most of which is preventable with accurate and timely diagnosis. ...