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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Small Molecule Inhibitors of trans-Translation with Broad Spectrum Antibacterial

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Because of the emergence of resistance to known antibiotics there is a critical need for new antibacterial agents especially against Gram negative pathogens trans Translation is a biochemical pathway that is essential to many bacterial species including Neisseria gonorrhoeae Shigella flexneri and Mycoplasma spp A high throughput assay of trans translatio ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Nucleoside Phosphonate Analogs for the Treatment of Adenoviral Infection

    SBC: TSRL, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Adenovirus can be a significant health risk for immune compromised patients both adult and pediatric patients In pediatric patients in particular complications associated with adenoviral infection include pneumonia urinary infections and hepatitis In the military setting adenoviruses are endemic in Department of Defense basic recruit training installation ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  3. Novel Inhibitors Targeting Early Steps of Human Cytomegalovirus Replication

    SBC: MICROBIOTIX, INC.            Topic: R

    DESCRIPTION provided by applicant Human cytomegalovirus HCMV infection is a major cause of morbidity and mortality in immunosuppressed patients especially recipients of solid organ or bone marrow transplants HCMV infection of neonates is associated with deafness mental retardation and mortality Although five anti viral drugs GCV val GCV CDV PFA Foscarnet have been approved and lice ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Cost-effective MHz rate Optical Coherence Tomography for biomedical applications

    SBC: WASATCH PHOTONICS, INC.            Topic: NIBIB

    DESCRIPTION provided by applicant During this SBIR Phase I project we propose to build and test in phantoms a prototype of an innovative cost effective Optical Coherence Tomography OCT system with a X increase in acquisition rate compared to commercially available systems Further development may add an additional X increased acquisition rate for a total of X Current market demand for ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Self-assembling density gradients for sickle cell diagnosis in low resource areas

    SBC: DAKTARI DIAGNOSTICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant The World Health Organization has recently recognized sickle cell disease as a major global health concern The highest rates of sickle cell disease and sickle cell trait are seen in malaria endemic developing countries which also have the most severe resource constraints especially on clinical laboratory infrastructure Daktari Diagnostics a person vent ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Synthetic microparticle malaria vaccine

    SBC: ARTIFICIAL CELL TECHNOLOGIES INC            Topic: NIAID

    DESCRIPTION provided by applicant This Phase II project will develop a novel synthetic microparticle vaccine for malaria using the T BT epitopes of the circumsporozoite CS protein of Plasmodium falciparum the causative agent of human malaria There is no approved vaccine for malaria a disease that causes up to million new infections and million deaths each year in the developing wor ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Dendritic Cell-Targeted HIV Vaccine Product

    SBC: AVANT IMMUNOTHERAPEUTICS, INC.            Topic: NIAID

    DESCRIPTION This proposal is a unique collaboration between a small but full capability biotechnology company and a premier academic institution and laboratory to develop a novel product for clinical trials to prevent HIV infection This proposal describes a vaccine product aimed to provide a feasible and nontoxic way to elicit strong immunity in humans to HIV proteins and it will provide an ad ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Diagnostic Assays for early Lyme Borreliosis using in-vivo expressed antigens

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    DESCRIPTION provided by applicant Current testing for Lyme disease is suboptimal because it requires two assay platforms including one with subjective interpretation of results and because it has lower sensitivity in the early stage of the illness Infection with Borrelia burgdorferi the causative agent of Lyme disease is transmitted by the bite of an Ixodid tick and results in uniformly lo ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Powered Walk/Run Prosthetic Ankle

    SBC: Springactive, Inc.            Topic: NICHD

    DESCRIPTION provided by applicant In the first phase of this project it was shown that by utilizing innovative technologies it was possible to allow below the knee amputees to walk and run using a single powered prosthetic device In the second phase of this project it will be shown that the key technological advancements and optimizations will allow the a single powered device to perform wa ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. An intervention to improve adolescent headache self-management

    SBC: Inflexxion, Inc.            Topic: NICHD

    DESCRIPTION provided by applicant A mobile based intervention to improve adolescentsandapos headache self management Abstract Headache pain is a common and significant problem for adolescents King et al As headaches become more frequent and severe the negative impact on happiness increases and adolescents report less satisfaction with their health and with their life Sillampaa ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health

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