Award Data

DESCRIPTION (provided by applicant): The development of an alternative to the currently available synthetic vascular prosthesis is of great value. Atherosclerosis vascular disease, in the form of coronary artery and peripheral vascular disease, is the leading cause of mortality in the United States. Despite vast improvements in the field of biomaterials, a useful biocompatible material is still no ...

DESCRIPTION (provided by applicant): Antisense oligonucleotides have generated enormous interest as therapeutic molecules since their initial demonstration in 1978, but their full utilization as effective human therapies has been hampered by inadequate drug delivery to the correct cellular compartment of the correct tissue. We have designed a water-based, ultra-small nanocapsule formulation for ...

The overall goal of the proposed research is to develop a comprehensive, efficient, and well-validated model for the prediction of the shape and thermal history of components manufactured using Laser Additive Manufacturing (LAM) processes. The proposedmodel will use a combined Eulerian-Lagrangian treatment for analyzing the interactions between the gas and particle phases, and the laser beam. The ...

DESCRIPTION (provided by applicant): Korosensor proposes to develop a skin interface friction transducer (SIFT) to prevent skin breakdown in diabetic mellitus patients, which can lead to foot ulceration and lower extremity amputation. The risk of lower extremity amputation is 15 to 46 times higher in diabetics than persons without diabetic mellitus, with the vast majority of diabetic foot compl ...

Diode laser present one of the most challenging thermal problems in industry. The small footprint and very high power levels combine to create extremely high heat fluxes in the vicinity of the diode. Tese heat flux levels raise the diode temperature,leading to lower lasing efficiency, wavelength shifts, and reduced diode lifetime. The cooling problem becomes even more difficult when combined wi ...

Diode laser present one of the most challenging thermal problems in industry. The small footprint and very high power levels combine to create extremely high heat fluxes in the vicinity of the diode. Tese heat flux levels raise the diode temperature,leading to lower lasing efficiency, wavelength shifts, and reduced diode lifetime. The cooling problem becomes even more difficult when combined wi ...

DESCRIPTION (provided by applicant): Hemorrhagic stroke following aneurysmal rupture represents 15% to 30% of all strokes, with greater than 40,000 deaths per year attributed to acute aneurysmal rupture in the United States alone. Additionally, another 28,000 to 36,000 acutely ruptured aneurysms are treated per year in the U.S. The incidence of an intracranial aneurysm in the general population h ...

DESCRIPTION (provided by applicant): Hemorrhagic stroke following aneurysmal rupture represents 15% to 30% of all strokes, with greater than 40,000 deaths per year attributed to acute aneurysmal rupture in the United States alone. Additionally, another 28,000 to 36,000 acutely ruptured aneurysms are treated per year in the U.S. The incidence of an intracranial aneurysm in the general population h ...

A novel method of intraweapon wireless communications using magnetic field transmissions was demonstrated during the Phase I portion of this program. Normal physical wire communication links cannot be expected to survive during and after targetpenetration. Therefore, various methods of wireless communication within a metal cylinder 15 inches in diameter and 10 feet in length were evaluated and c ...

DESCRIPTION (provided by applicant): The goal of this proposal is to facilitate the design of innovative treatment regimens employing METVAN for breast cancer and brain tumor patients. Among the 25 bis(cyclopentadienyl)vanadium(IV) and 15 oxovanadium(IV) compounds synthesized and evaluated for anticancer activity, bis(4,7-dimethyl-1,10-phenanthroline) sulfatooxovanadium(IV) [METVAN] was identified ...