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Award Data
The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Structure-guided neutralizing antibodies developed using EpiVolve technology
SBC: ABBRATECH INC. Topic: NIAIDAbstract Current strategies for developing neutralizing Abs are not effective and typically involve screening IgGs from recovered patients. Pandemic viruses evolve for mutations that can shield their epitopes from host immune surveillance system, so a lot of important epitopes will be missed. Even after neutralizing Abs isolated are from human sample, they still need further characterization using ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Monitoring Immunotherapy Response via Gene Silencing Landscapes in Cell-Free DNA
SBC: BINARY GENOMICS, INC Topic: 102ABSTRACT: Immunotherapies produce remarkable, long-term responses in subsets of patients with non-small cell lung cancer, but unfortunately, most patients do not respond to such treatment. Current biomarkers to predict which patients will benefit have limited accuracy, and decisions to continue or suspend treatment are mainly guided by monitoring of radiographic changes in tumor size. However, unu ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Development of an endometrial ablation drug-device combination to treat heavy menstrual bleeding
SBC: GYNION, LLC Topic: NICHDPROJECT SUMMARY Over 10 million women in the US and 100 million women globally suffer from Heavy Menstrual Bleeding (HMB). Oral medications lack effectiveness and, like hormonal IUDs (intrauterine devices), have significant side effects. Currently available endometrial ablation options, which is another therapeutic alternative, are complex and require advanced anesthesia, which significantly limit ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
IL-17A mRNA-targeted oligonucleotide therapeutics in Idiopathic Pulmonary Fibrosis (IPF)
SBC: TARGETSITE THERAPEUTICS CORPORATION Topic: NHLBIAbstract. Idiopathic pulmonary fibrosis (IPF) is a progressive fibroproliferative disorder affecting ∼3 million people worldwide with function-limiting progressive symptoms and a 2-3 year median survival time from diagnosis. While the etiology of IPF is not clear, genetic factors, environmental exposures and microbial pathogens have been identified as IPF risk factors. Pirfenidone and nintedanib ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Development of a sample preparation protocol for 3D kidney ultrastructural analysis and immunolabeling by light microscopy
SBC: panluminate Inc. Topic: 400Abstract The success of cohort studies such as the NIDDK Kidney Precision Medicine Project (KPMP) with its massive amount of samples depends on the cost and time-efficient evaluation of kidney biopsies at multiple scales. Assessing the structure of kidney tissue at the nanoscale (~10 nm) and evaluating the 3-D distribution of protein biomarkers in that context is, however, currently severely limit ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Simultaneous H2 Generation and Compression with Intermediate-Temperature Solid-Oxide Membranes
SBC: PRECISION COMBUSTION, INC. Topic: T7Precision Combustion, Inc. (PCI) proposes to develop and demonstrate simultaneous H2 generation and compression with intermediate-temperature solid-oxide membranes. The innovation is based on a novel cell architecture and materials, and processing techniques recently developed at PCI. Proof of concept testing of the new cell architecture indicated potential to be to be lightweight and presents sev ...
STTR Phase I 2023 National Aeronautics and Space Administration -
TEAMS Fault Management Extension for State-based Design and Simulation
SBC: QUALTECH SYSTEMS, INC. Topic: S17Reliable Vamp;V and testing of fault management (FM) during design, implementation and operations is an essential part of systems engineering design and development of critical space programs such as the SLS, Gateway and Artemis.nbsp;NASArsquo;s Mission and Fault Management group currently utilizes SAM to assess nominal andnbsp;FM algorithms prior to full-scale real-time testing, to proactively ch ...
SBIR Phase I 2023 National Aeronautics and Space Administration -
Dynamic Adaptive Mesh Refinement for Wall Modeled LES of Complex Configurations
SBC: SCIENTIFIC SIMULATIONS, LLC Topic: A1The objective of this proposal is the development and demonstration of a dynamic adaptive mesh refinement (AMR) capability for wall modeled large eddy simulations (WMLES) of complex configurations using arbitrary grid types including unstructured grids with hybrid element types. Our approach consists of linking legacy CFD codes to an octree mesh subdivision library, which is highly scalable and ca ...
SBIR Phase I 2023 National Aeronautics and Space Administration -
Autonomous Space Traffic Management Technologies for Small Spacecraft Swarms and Constellations
SBC: SYRNATEC INC Topic: Z8Syrnatec proposes a novel robust solution for the ldquo;Onboard Devices for Deorbit and/or Disposal of Single Spacecraftrdquo; via the development of a hardware-based energy harvesting and controller module for electrodynamic-tether (EDT) systems. Recently, passive EDTs have successfully demonstrated deorbit of small spacecraft (e.g., Millennium Space Systemrsquo;s Dragracer mission in 2021). Our ...
SBIR Phase I 2023 National Aeronautics and Space Administration -
Nanoarray based monolithic contaminant filter for efficient submicron PM and NH3 removal
SBC: 3D ARRAY TECHNOLOGY LLC Topic: C5626eC56-26e-273790The proposed SBIR phase I project aims to develop a new class of low cost nanoarray based monolithic contaminant filter for Clean Hydrogen Production and Separation from Coal Waste, Biomass, MSW and Plastics produced syngas. It is anticipated that the contaminant filter can capture > 95 % of the heavy metal particulate matter (PM) with submicron size and remove > 95 % of NH3 in the s ...
SBIR Phase I 2023 Department of Energy