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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Hydrogel microparticle technology for high-throughout screening of chimeric antigen receptor-T cells based on single cell effector function

    SBC: PARTILLION BIOSCIENCE CORP            Topic: 300

    ABSTRACT Engineered cell therapies are becoming a pillar of medicine, along with molecular and genetic interventions. In particular, chimeric antigen receptor (CAR)-T cell therapies have had a number of FDA approvals in the last 5 years targeting hematologic malignancies. To extend the success of these therapies, especially for the treatment of solid tumors, a more thorough understanding of how CA ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Quantitative Analysis of Cancer-associated EVs

    SBC: Cellarcus Biosciences, Inc.            Topic: 102

    Abstract All cells in the body, including tumor cells, release small vesicles that can be found in blood, cerebrospinal fluid, and even urine. Because each vesicle was released by a specific cell, their analysis can tell us about the cells from which they came, including whether that cell was infected, cancerous, or malfunctioning in some way. We will develop assays and kits to enable cancer resea ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Functionally Closed Purification and Elution of Untouched Cells using Cleavable Magnetic Beads with Digital Magnetic Sorting

    SBC: FERROLOGIX INC            Topic: 400

    Project Summary Isolation of specific and well-defined cell types to produce next generation cellular therapies remains a significant scale up and scale out challenge for autologous and allogeneic therapies. Through primary customer interviews of cell therapy developers, we learned there is an unmet need for scalable cell sorting systems that can isolate rare cell types on multiple markers in prod ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Therapeutic UV Disinfection System to Prevent Catheter Related Bloodstream Infections (CRBSIs) in Patients with Peripherally Inserted Central Catheters (PICCs)

    SBC: PURACATH MEDICAL INC            Topic: NIAID

    Abstract The goal of PuraCath’s Commercial Readiness Pilot is to prepare for commercialization of a therapeutic system for disinfection of a needleless connector for Peripherally Inserted Central Catheters that reduces the risk of intraluminal colonization as a source of catheter-related bloodstream infections. The system uses ultraviolet light to eliminate microbes and biofilm derived from fung ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Scalable single-cell workflow for multiomic analyses of chromatin interactions, accessibility, gene expression and cell surface proteins to unravel mechanisms of cellular diversity

    SBC: ARIMA GENOMICS, INC.            Topic: 400

    Scalable single-cell workflow for multiomic analyses of chromatin interactions, accessibility, gene expression and cell surface proteins to unravel mechanisms of cellular diversity Arima Genomics Project Summary/Abstract All cells in the human body carry the same DNA sequence and yet individual cells are highly diverse in identity, morphology, proliferation, and function, leading to enormous heter ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. MomNet: Development of a Coach-Training Program for an Empirically Supported, Guided ehealth Intervention for Depressed Mothers

    SBC: OREGON RESEARCH BEHAVIORAL INTERVENTION STRATEGIES, INC.            Topic: 104

    Project Summary/Abstract Economically disadvantaged mothers of young children experience disproportionately high rates of depressive symptoms, yet often do not receive treatment due to instrumental and psychological barriers. Remission of maternal depression relates to improvements in both parenting behavior and child functioning, suggesting that treatment of maternal depression has the potential ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Developing a kit-based research use only (RUO) translocation assay for deployment as a lab developed test (LDT) toward changing outcomes for patients with driver-negative tumors

    SBC: ARIMA GENOMICS, INC.            Topic: NCI

    Developing a kit-based research use only (RUO) translocation assay for deployment as a lab developed test (LDT) toward changing outcomes for patients with driver-negative tumors (RFA sub-section: Technology platform for Cancer Diagnostics) SUMMARY Nearly 1M patients are diagnosed with advanced stage cancer per year. One case dear to Arima is a teenage girl who was diagnosed with advanced brain can ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Clinical readiness of Uzap- the minimally invasive Overactive Bladder treatment

    SBC: STELLARTECH RESEARCH CORPORATION            Topic: 400

    AbstractOveractive bladder (OAB) severely impacts over 12% of the adult population in the United States – roughly 30 million people (Irwin, et al., 2006). Pressing and frequent urges to urinate, arousal from sleep, and sometimes incontinence, result in immense psychosocial and financial costs, leading to an estimated annual economic burden of rt$70B in the US alone (Reynolds, et al., 2016). Curr ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Biocascade inlet

    SBC: AEROSOL DYNAMICS INC            Topic: NIAID

    Project Summary Respiratory infections are the most common reason for doctor visits and the third leading cause of deaths. Viruses are the causative agents of most respiratory tract infections. Knowledge of the transmission modes for pathogenic respiratory viruses is critical for improving mitigation strategies that safeguard public health, but understanding their transmission mechanisms is hamper ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. RSK3 Anchoring Disruptor Therapy for Heart Failure

    SBC: CARDIAC RSK3 INHIBITORS, LLC            Topic: NHLBI

    Novel therapeutic approaches are desperately needed in an expanding patient population to improve both the survival and quality of life for patients with or susceptible to heart failure. Research over the last two decades has established p90 ribosomal S6 kinase type 3 (RSK3) as a pivotal regulator of pathological cardiac remodeling, including in mouse models of pressure overload and genetic cardio ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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