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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
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A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
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SBC: PARMEDICS, INC. Topic: NHLBI
Lay Abstract: Asthma is a widely prevalent condition that affects 1 in 12 adults in the United States and an estimated 300 million individuals worldwide. Mild asthma is well controlled by current standard of care (SOC), including long-acting b-adrenergic receptor agonists, anti- leukotrienes and/or inhaled corticosteroids. As patients progress to severe disease add-on treatment options can include ...STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
SBC: PROTERIS BIOTECH, INC. Topic: NEI
PROJECT SUMMARYThe ocular surface (OcS) comprises the stratified squamous epithelia of the cornea/conjunctiva, its adnexa, and the overlying tear film. OcS disease disrupts the normal developmental progression, maturation, and turnover of OcS epithelia, causing “epitheliopathy” characterized by cell damage, barrier disruption and programmed cell death. OcS disease initiated by tear dysfunction ...STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
SBC: Phononz Inc Topic: NEI
Retinal degeneration involving progressive deterioration and loss of function of photoreceptors is a major cause of permanent vision loss worldwide. Strategies to treat these incurable conditions incorporate retinal prostheses via electrically stimulating surviving retinal neurons with implanted devices in the eye, optogenetic therapy, and sonogenetic therapy. Existing challenges of these strategi ...STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
3D microprinting-enabled microinjection needle arrays for enhanced therapeutics delivery into the brainSBC: SEETRUE TECHNOLOGY, LLC Topic: 101
PROJECT SUMMARY Microinjection technologies underlie many research and clinical applications that require gene and cell delivery, including studies and emerging treatments of neurological conditions (e.g., neurodegenerative diseases, traumatic brain injury, and cancer). Unfortunately, challenges associated with the microinjection tools by which the viral vectors and cells inherent in these applica ...STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
SBC: Flux Therapeutics, LLC Topic: 400
Fibrosis is an aberrant wound healing process characterized by progressive accumulation of extracellular matrix that ultimately destroys organ function. Progressive fibrosis is inherent to chronic kidney disease (CKD), which often leads to end-stage renal disease. Although patients can be maintained by hemodialysis while awaiting transplantation, their’s and their care-giver’s quality of life ...STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
SBC: MICROCURES INC Topic: NEI
The cornea is one of the most important tissues in the eye and its transparency is critical for good visual function in humans. Corneal tissue injuries are the most common, everyday issue for practicing ophthalmologists and can run the gamut in severity. Healing of large corneal wounds, such as alkali burns, involves extended migration of epithelial cells as well as reinnervation of the cornea. Ho ...STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
SBC: DARE BIOSCIENCE, INC. Topic: NICHD
In the United States, one in ten babies is born prematurely. The earlier in pregnancy a baby is born, the more likely they will have an extended hospital stay, as well as serious health complications such as respiratory distress syndrome, necrotizing enterocolitis, deafness, vision problems and cerebral palsy. Maternal stress is a well-established risk factor for preterm birth, and recent studies ...STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
SBC: MODALITY.AI , INC Topic: NIDCD
PROJECT SUMMARY Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease resulting in the progressive loss of limb, trunk, and head and neck (bulbar) motor function and is the most common adult-onset motor neuron disease. The disease is characterized by significant across-patient heterogeneity in the onset region and in pattern and progression rate, making early and accurate diagno ...STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
SBC: BORROW MY GLASSES LLC Topic: NIA
1 Approximately 6.5 million Americans aged 65 and older live with dementia, supported by more than 11 million2 unpaid family caregivers. These numbers are projected to rise exponentially in the coming decades fueling the3 need to develop scalable ways to support dementia caregivers. The need to empower dementia caregivers to4 continue providing care while maintaining their own health and well-bein ...STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
SBC: NEUCYTE INC Topic: NIA
Abstract Alzheimer Disease (AD) is characterized by b-amyloid (Ab) accumulation, neurofibrillary tangles (NFTs), neuroinflammation, and widespread neuronal and synaptic loss. To date, there are no therapies available, although immunotherapies i.e., Lecanemab hold promise. Species differences underlie the difficulties in translating therapeutics uncovered in animal models for human brain-specific d ...STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health