Award Data

DESCRIPTION (provided by applicant): This Phase I Small Business Technology Transfer study between Materia, Inc. and the University of Kansas is focused on the development of high-load, oligomeric reagents and scavenging agents derived from ring-opening metathesis polymerization (ROMP), one of several core metathesis technologies at Materia, Inc. The specific aims during Phase I focus on three are ...

Highly-Multiplexed Accurate HLA Typing using PAP and Digital Bead Technologies

DESCRIPTION (provided by applicant): We propose clinical evaluation and optimization studies of time-resolved fluorescence spectroscopy (TR-LIFS) technique for the intraoperative identification of tumor vs. normal brain during neurosurgical resection of brain tumors. A critical need currently for neurosurgeons operating on infiltrative glial neoplasms is the ability to distinguish between normal ...

DESCRIPTION (provided by applicant): Chronic wounds are non-healing wounds such as diabetic ulcers and pressure ulcers. Each year, 6.5 million cases occur in the U.S., costing the economy billions of dollars. Cost-effective and efficient management of chronic wounds depends on quick assessment and diagnosis of the underlying reasons for compromised healing. Ischemia is one of the main complication ...

DESCRIPTION (provided by applicant): Project Summary: The laboratory mouse is an essential experimental resource for modern biomedical research. Scientists currently use hundreds of varieties and strains of mice, and generate over 10 million individual animals each year. Tens of millions of dollars of NIH funding annually support mouse model research, with millions directly allocated to the mainte ...

DESCRIPTION (provided by applicant): The increasing costs of therapy and the demonstrated benefits of improved treatment efficacy with early detection are important incentives to develop tumor diagnostic agents of greater specificity and sensitivity. Paramagnetic gadolinium complexes are widely used as MRI (magnetic resonance imaging) contrast agents to improve sensitivity and/or specificity duri ...

DESCRIPTION (provided by applicant): Despite concerted efforts to improve therapy, five year survival rates for patients with advanced stage oral squamous cell carcinoma (SCC) remain discouragingly low. Clearly, early detection combined with strategies for local intervention, such as chemoprevention prior to SCC development, could dramatically improve clinical outcomes. The results of previously c ...

DESCRIPTION (provided by applicant): Nesher Technologies, Inc. (NTI) licensed from UCLA the IP for a revolutionary suite of ultrasensitive biodetection technologies involving alternating laser excitation (ALEX) fluorescence spectroscopy. These technologies were developed at the UCLA Single Molecule Biophysics Laboratory (headed by Prof. Shimon Weiss). NTI proposes to apply one of these technologie ...

DESCRIPTION (provided by applicant): Candida is a fungus that is among the most common causes of infections in hospitalized patients in the United States and worldwide. Candida spp. are one of the most common microbes that infect the blood and urine of hospitalized patients. The cost associated with Candida blood infections alone exceeds at least $1 billion per year in the US. Even with therapy, 4 ...

DESCRIPTION (provided by applicant): This proposal will lead to identification of gene variants that increase the risk of developing cardiovascular disease. The underlying hypothesis is that systematic genetics conducted in model organisms enables the identification of disease-specific gene modules. This hypothesis will be tested in Phase I through the following Aims: (1) Create a database of phen ...