Award Data

ABSTRACT Loneliness contributes to physical and psychological chronic illnessesfunctional decline and mortality in older adultsThe fast growing older population coupled with the worsening shortage of caregivers will soon present our nation with severe societal and economic challengesOlder adults often struggle to maintain quality of life and independence in the presence of chronic diseases and iso ...

Project Summary Alzheimer s diseaseADis a debilitating neurodegenerative disease affecting roughlyinpeople over the age ofInthe total cost of AD in the United States was estimated at $billion and is predicted to climb to $trillion by the yearDespite enormous efforts invested in finding a cureit has proven extremely difficult to develop treatments for ADContributing factors behind this difficulty i ...

Project SummaryOsteoarthritisOAis the most common type of arthritisaffecting overmillion adults in the United States inand represents overof medical office visits according to the Centers for Disease Control and Prevention and the National Institutes of HealthOverof individuals overhave symptomatic OA and reduced mobility due to the diseaseOA pain is often mitigated with conservative treatment app ...

Prevention of biofilms on invasive medical devices has the potential to significantly reduce hospital acquired infections and improve patient outcomesProsthetic joint infectionsPJIsacquired from orthopedic implantsoften the result of microorganism contamination on the implant surface during surgeryaffect patient recoveries and can lead to significant mortalitiesOne approach for reducing the incide ...

Through ayear collaboration between Boston UniversityBUand the Massachusetts General HospitalMGHwe have built insulin only and bihormonal con gurations of our bionic pancreasBPand extensively tested them in inpatientoutpatientand real world home use studies in people with typediabetesT DWe have also conducted preliminary clinical studies testing the insulin only con guration of our BP in people wi ...

DESCRIPTION (provided by applicant): Chronic diseases of aging account for a significant proportion of healthcare spending and result in a painful and limiting existence for many tens of millions of Americans and hundreds of millions of people around the world. Recursion Pharmaceuticals has developed a drug discovery platform that re-purposes known drugs for the treatment of such diseases. The pla ...

PROJECT SUMMARY Pressure Management Technologies for Oxygenation of Implanted Insulin Secreting Cells The overall goal of the SBIR project is to develop an advancedminiaturized implantable electrochemical oxygen generator that supplies oxygen at well regulated dose and concentration to cells within an immunoisolation deviceso as to ensure their viability and function at high density and minimize o ...

In this SBIR effort we will develop a balanced detection analog photonic link consisting of a DFB laser, a dual-output high-speed, low-Vp mach-zehnder modulator (MZM) and a high-power, high-linearity balanced photodetector (BPD) using a dual-core, single mode, multicore fiber (MCF) that is supplied by our subcontractor, OFS. We will design, fabricate and characterize (phase I) the MZM and the BPD, ...

Photonic integration, and specifically silicon photonics, has emerged as one of the leading solutions for maintaining or improving the performance of optical systems while addressing the requirements related to size, weight, and power (SWaP). Photonic integrated circuits (PICs), which integrate multiple photonic elements onto a single chip, are specifically suited to providing the complexity and f ...

Over the past three years an entirely new cancer treatment paradigm has emerged following the FDA approval ofdifferent checkpoint inhibitors for a number of indications includingmetastatic melanoma and non small cell lung cancerThese new agents work by effectively releasing the brakes on the immune system that normally limit the body s natural responses to tumor cells and have generated long term ...