Award Data

DESCRIPTION provided by applicant Diabetes and diabetes related co morbidities are at epidemic proportions and an enormous burden to our healthcare system Although there has been significant progress in defining the causative factors and molecular mechanisms involved in both type and type diabetes it remains an overwhelming challenge to identify efficacious therapeutic modalities Novel a ...

Interfaces on existing military chemical/biological protection garments are not designed to fully eliminate macroscopic and microscopic air gaps at folds, fabric surfaces, or hook-and-loop closures, and thus do not provide a hermetic barrier against exposure. Creare proposes to develop a hermetic garment closure system that seals macroscopic and microscopic gaps at interfaces and closures and pro ...

Chemical, biological, or toxin attacks in military and civilian settings are a serious and growing concern. Standard first aid for exposure to some chemical warfare agents and toxins includes the immediate administration of relevant antidotes using an autoinjector. When an attack occurs, pre-filled autoinjectors must be immediately available and thus highly portable, and they must be suitable fo ...

A NEW TECHNIQUE HAS BEEN DEVELOPED TO ASSAY CLOTTING FACTORS: SOLID-PHASE FIBRINOGEN AND LABELLED FIBRINOGEN TOGETHER ARE USED AS A SUBSTRATE TO DETECT THROMBIN GENERA- TED FROM THE CLOTTING CASCADE. WHEN THROMBIN CLEAVES BOTH FORMS OF FIBRINOGEN TO FIBRIN, THE LABELLED FIBRIN IN SOLU- TION ASSOCIATES WITH THE SOLID PHASE. THIS TECHNIQUE, WHICHHAS BEEN NAMED "ENZYME-LINKED COAGULATION ASSAY" OR EL ...

A NOVEL HORIZONTAL LIGHT PATHVISION ENHANCING SYSTEM (HLP-VES) CAPABLE OF 2X TO 6X MAGNIFICATION AND MOUNTED ACROSS THE FACIAL PLANE WILL BE STUDIED 1. SURVEY OF CURRENT USAGE OF TELESCOPIC VISION AIDS; 2. OPTIMIZATION OF OPTICAL DESIGN IN DESIRABLE MAGNIFICATION POWERS INCORPORATING THE HLP-VES PRINCIPLE; 3. PRELIMINARY DESIGNS OF OPTICAL CHASSIS AND MOUNTING; 4. IDENTIFICATION OF COMPONENT SOURC ...

THE LONG-TERM RESEARCH OBJECTIVE IS TO MAKE COMMERCIALLY AVAILABLE A MICROCOMPUTER-BASED SYSTEM TO FACILITATE PATIENT SELF-CONTROL OF INSULIN DEPENDENT DIABETES MELLITUS. THIS COMPREHENSIVE ""DIABETES IN SELF-CONTROL (DISC) SYSTEM'' IS COMPOSED OF: 1.AN INSTRUCTIONAL AND REINFORCEMENT COMPONENT FOR COMPUTER ASSISTED HOME BLOOD GLUCOSE MONITORING; 2.A COMPONENT WHICH PROVIDES COMPUTER ASSISTED INST ...

Not Available

Modify Phase I product and develop the full Arise product. Modify initial prototype based on feedback and fully develop all six modules. PUBLIC HEALTH RELEVANCE

DESCRIPTION (provided by applicant): The Center for Disease Control (CDC) estimates the yearly incidence of mild Traumatic Brain Injury (mTBI) at approximately 1.2 million cases in the United States alone. Approximately 1/3 of these injuries occur in football. The Principal Objective of this NIH Phase IIb SBIR project is to expand the utility of the current, and now commercially available, InSite ...

DESCRIPTION (provided by applicant): Congestive heart failure is a major cause of morbidity and mortality in the United States. While progress in conventional treatments is making steady and incremental gains to reduce heart failure mortality, there is a critical need to explore new therapeutic approaches. It is now apparent that gene therapy has broader potential in diseases such as congestive he ...