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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Low-temperataure plasma decontamination of pharmaceutical manufacturing fill/finish operations

    SBC: MixZon, Inc.            Topic: 100

    Project Summary AbstractThe goal of the proposed SBIR program is to develop a pharmaceutical manufacturing decontamination system using the innovative PSI atmospheric pressure microwave microplasma technologyCommercialization of this technology is targeted to replace the use of vapor phase hydrogen peroxideVPHPin parenteral drug manufacturing facilitiesincluding barrier isolator sterilization syst ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. Intravascular molecular-structural NIRF-IVUS imaging of coronary artery disease

    SBC: IntraVascular Imaging, Inc.            Topic: NHLBI

    The goal of this Phase I STTR project is to constructoptimizeand test a clinically viable intravascular near infrared fluorescence intravascular ultrasoundNIRF IVUSimaging catheter for simultaneous molecular and structural diagnosis of coronary artery diseaseCADCAD is a worldwide leading cause of death and disabilityincluding acute myocardial infarctioncongestive heart failureand sudden cardiac de ...

    STTR Phase I 2018 Department of Health and Human Services
  3. Tortuous vascular accessibility with a novel coaxial active deflectable microcatheter

    SBC: Agile Devices, Inc.            Topic: NHLBI

    Project Summary The goal of this project is to introduce a new microcatheter that will significantly improve an interventional radiologist s ability to navigate across small blood vesselsMicrocatheters are designed to reach small vascular targets from access points such as the femoral or radial arterieslocated up tocm awayInterventional radiologists use these devices to treat a wide variety of ail ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. A Resonator for Pulsed ODNP Spectroscopy to Study Surface Hydration Dynamics

    SBC: BRIDGE 12 TECHNOLOGIES, INC.            Topic: 400

    Project SummaryAbstractThe proposed research focuses on the development of a turn key resonator for liquid state Overhauser Dynamic Nuclear PolarizationODNPspectroscopy to study the site specific translational dynamics of water molecules located at the interface of bio macromolecules such as membrane proteinsIt will allow researchers to readily perform ODNP experiments in a state of the art commer ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Multiplexed Bead-based In Vitro Pediatric Allergy Test

    SBC: AMBERGEN, INC            Topic: NIAID

    The CDC reports that food allergy incidence in the U Sis risingwithof children now afflicted andhaving a history of severe and potentially life threatening reactionsIn order to reduce this high incidencenew guidelines recently issued by the NIAID and also by leading allergists recommend that children betweenmonths of age be introduced to highly allergenic foods such as peanutsmilk and eggsIn addit ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Universal Influenza Vaccine

    SBC: VERSATOPE THERAPEUTICS, INC.            Topic: NIAID

    Abstract A universal influenza vaccine that is capable of protecting against all strains of influenza is a high priorityThe Centers for Disease Control andampPreventionCDCestimate the economic impact of seasonal influenza in the United States to range from $to $billion and pandemic influenza to range from $to $billionThe proposed research directly addresses the limitations of both pandemic and sea ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Point-of-care diagnostic test for T. cruzi (Chagas) infection

    SBC: Kephera Diagnostics, LLC            Topic: NIAID

    Project Summary Chagas diseasecaused by infection with the parasite Trypanosoma cruziis the most prevalent parasitic disease in the western hemisphereinfectingmillion individuals and with overmillion at riskThe infection is transmitted by an insect vectorbut can also be acquired through blood transfusionorgan transplantor congenitallyFollowing a brief acute phasethe parasite persists for years in ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Development of a Human Liver Microphysiological System For Alcoholic Liver Disease

    SBC: Emulate, Inc.            Topic: 500

    PROJECT SUMMARYAlcoholic liver diseaseALDincludes a broad range of progressive disease stagesfatty liveralcoholic steatohepatitisASHliver fibrosisliver cirrhosisand hepatocellular carcinomaIn spite of being one of the major causes of morbidity and mortality in the worldthere are currently no effective strategies that can preventtreat or monitor the progress of ALD owing primarily to lack of human ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. An Automated Device for High Yield Mesenchymal Stem Cell Extraction

    SBC: CG Scientific, Inc.            Topic: NIBIB

    Project Summary Abstract This Phase II project aims to develop an automated system for extracting mesenchymal stem cellsMSCsalso known as multipotent stromal cellsfrom adipose tissues for treating many serious diseasesincluding myocardial infarctiongraft versus host diseaseand a variety of autoimmune diseasesOverclinical trials to date have established the feasibilitysafetyand in some cases effica ...

    SBIR Phase II 2018 Department of Health and Human Services
  10. Development of a kit for the targeted depletion of abundant sequencesfromDNA/RNA libraries

    SBC: ARC Bio, LLC            Topic: NIAID

    ABSTRACT Next generation sequencingNGShas the potential to revolutionize how infectious disease is diagnosed and treatedenabling the detection of a wide variety of pathogens in a single testHoweverdespite the increasing adoption of molecular diagnostics in clinical microbiology labsNGS has not become widespread due to its costturnaround timeand the technical and computational expertise required to ...

    SBIR Phase II 2018 Department of Health and Human Services

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